Meldal Birgit H M, Forner-Martinez Oscar, Costanzo Maria C, Dana Jose, Demeter Janos, Dumousseau Marine, Dwight Selina S, Gaulton Anna, Licata Luana, Melidoni Anna N, Ricard-Blum Sylvie, Roechert Bernd, Skyzypek Marek S, Tiwari Manu, Velankar Sameer, Wong Edith D, Hermjakob Henning, Orchard Sandra
European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom
European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
Nucleic Acids Res. 2015 Jan;43(Database issue):D479-84. doi: 10.1093/nar/gku975. Epub 2014 Oct 13.
The IntAct molecular interaction database has created a new, free, open-source, manually curated resource, the Complex Portal (www.ebi.ac.uk/intact/complex), through which protein complexes from major model organisms are being collated and made available for search, viewing and download. It has been built in close collaboration with other bioinformatics services and populated with data from ChEMBL, MatrixDB, PDBe, Reactome and UniProtKB. Each entry contains information about the participating molecules (including small molecules and nucleic acids), their stoichiometry, topology and structural assembly. Complexes are annotated with details about their function, properties and complex-specific Gene Ontology (GO) terms. Consistent nomenclature is used throughout the resource with systematic names, recommended names and a list of synonyms all provided. The use of the Evidence Code Ontology allows us to indicate for which entries direct experimental evidence is available or if the complex has been inferred based on homology or orthology. The data are searchable using standard identifiers, such as UniProt, ChEBI and GO IDs, protein, gene and complex names or synonyms. This reference resource will be maintained and grow to encompass an increasing number of organisms. Input from groups and individuals with specific areas of expertise is welcome.
IntAct分子相互作用数据库创建了一个全新的、免费的、开源的、经过人工整理的资源库——复合物门户（www.ebi.ac.uk/intact/complex），通过该资源库可以整理来自主要模式生物的蛋白质复合物，并可供搜索、查看和下载。它是与其他生物信息学服务密切合作构建的，并填充了来自ChEMBL、MatrixDB、PDBe、Reactome和UniProtKB的数据。每个条目都包含有关参与分子（包括小分子和核酸）的信息、它们的化学计量、拓扑结构和结构组装。复合物用其功能、特性和复合物特异性基因本体（GO）术语的详细信息进行注释。整个资源库使用一致的命名法，提供系统名称、推荐名称和同义词列表。使用证据代码本体使我们能够指出哪些条目有直接实验证据，或者该复合物是否基于同源性或直系同源性推断得出。数据可使用标准标识符进行搜索，如UniProt、ChEBI和GO ID、蛋白质、基因和复合物名称或同义词。这个参考资源库将得到维护并不断扩展，以涵盖越来越多的生物。欢迎具有特定专业领域的团体和个人提供意见。
