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免疫表位数据库(IEDB):2024年更新

The Immune Epitope Database (IEDB): 2024 update.

作者信息

Vita Randi, Blazeska Nina, Marrama Daniel, Duesing Sebastian, Bennett Jason, Greenbaum Jason, De Almeida Mendes Marcus, Mahita Jarjapu, Wheeler Daniel K, Cantrell Jason R, Overton James A, Natale Darren A, Sette Alessandro, Peters Bjoern

机构信息

Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

Leidos, Inc, San Diego, CA 92121, USA.

出版信息

Nucleic Acids Res. 2025 Jan 6;53(D1):D436-D443. doi: 10.1093/nar/gkae1092.

Abstract

Over the past 20 years, the Immune Epitope Database (IEDB, iedb.org) has established itself as the foremost resource for immune epitope data. The IEDB catalogs published epitopes and their contextual experimental data in a freely searchable public resource. The IEDB team manually curates data from the literature into a structured format and spans infectious, allergic, autoimmune, and transplant diseases. Here, we describe the enhancements made since our 2018 paper, capturing user-directed updates to the search interface, advanced data exports, increases in data quality, and improved interoperability across related resources. As we look forward to the next 20 years, we are confident in our ability to meet the needs of our users and to contribute to the broader field of data standardization.

摘要

在过去20年里,免疫表位数据库(IEDB,iedb.org)已成为免疫表位数据的首要资源。IEDB在一个可免费搜索的公共资源中编目已发表的表位及其相关实验数据。IEDB团队将文献中的数据手动整理成结构化格式,涵盖传染病、过敏、自身免疫和移植疾病。在此,我们描述自2018年论文发表以来所做的改进,包括捕获用户导向的搜索界面更新、高级数据导出、数据质量提升以及相关资源间更好的互操作性。展望未来20年,我们有信心满足用户需求,并为更广泛的数据标准化领域做出贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e32/11701597/540f0e17e7e4/gkae1092figgra1.jpg

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