羟氯喹诱导的急性泛发性脓疱性皮病伴HLA分型
Hydroxychloroquine-induced acute generalized exanthematous pustulosis with HLA-typing.
作者信息
Zheng Qiaoli, Jin Na, Cheng Hao
机构信息
Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
出版信息
Pharmacogenomics. 2024;25(14-15):569-572. doi: 10.1080/14622416.2024.2430167. Epub 2024 Nov 18.
Abstract
Acute generalized exanthematous pustulosis (AGEP) is a rare drug reaction characterized by numerous pustules on an erythematous base. In some cases, hydroxychloroquine (HCQ) can cause AGEP. There is an association between HLA genes and AGEP according to pharmacogenomic studies. In this case report, we present the case of a 36-year-old female who developed HCQ-induced AGEP with HLA-typing. According to our findings, the patient had HLA-B 58:01, HLA-C 08:01, and HLA-A 02:06. A pharmacoeconomic perspective of HLA genotyping before drug prescription is shown in this result.
摘要
急性泛发性脓疱性皮病（AGEP）是一种罕见的药物反应，其特征为在红斑基础上出现大量脓疱。在某些情况下，羟氯喹（HCQ）可导致AGEP。根据药物基因组学研究，HLA基因与AGEP之间存在关联。在本病例报告中，我们呈现了一名36岁女性发生HCQ诱导的AGEP并进行HLA分型的病例。根据我们的研究结果，该患者具有HLA - B 58:01、HLA - C 08:01和HLA - A 02:06。此结果显示了在药物处方前进行HLA基因分型的药物经济学观点。
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本文引用的文献
1
Association between alleles and beta-lactam antibiotics-related severe cutaneous adverse reactions.等位基因与β-内酰胺类抗生素相关严重皮肤不良反应之间的关联。
Front Pharmacol. 2023 Sep 19;14:1248386. doi: 10.3389/fphar.2023.1248386. eCollection 2023.
2
Genotyping alleles to predict the development of Severe cutaneous adverse drug reactions (SCARs): state-of-the-art.基因分型等位基因以预测严重皮肤不良反应（SCAR）的发生：最新进展。
Expert Opin Drug Metab Toxicol. 2021 Sep;17(9):1049-1064. doi: 10.1080/17425255.2021.1946514. Epub 2021 Jul 8.
3
Characterizing the adverse dermatologic effects of hydroxychloroquine: A systematic review.描述羟氯喹的不良皮肤作用：一项系统综述。
J Am Acad Dermatol. 2020 Aug;83(2):563-578. doi: 10.1016/j.jaad.2020.04.024. Epub 2020 Apr 11.
4
Does hydroxychloroquine combat COVID-19? A timeline of evidence.羟氯喹能对抗新冠病毒吗？证据时间表。
J Am Acad Dermatol. 2020 Jul;83(1):e33-e34. doi: 10.1016/j.jaad.2020.04.031. Epub 2020 Apr 10.
5
Cephalexin-induced acute generalized exanthematous pustulosis.头孢氨苄诱发的急性泛发性脓疱性皮疹病
Dermatol Reports. 2018 Oct 1;10(2):7686. doi: 10.4081/dr.2018.7686.
6
Culprit Drugs Induce Specific IL-36 Overexpression in Acute Generalized Exanthematous Pustulosis.致病药物可导致急性泛发性发疹性脓疱病中特定的白细胞介素-36 过度表达。
J Invest Dermatol. 2019 Apr;139(4):848-858. doi: 10.1016/j.jid.2018.10.023. Epub 2018 Nov 2.
7
Hydroxychloroquine-induced hyperpigmentation in systemic diseases: prevalence, clinical features and risk factors: a cross-sectional study of 41 cases.系统性疾病中羟氯喹诱导的色素沉着：患病率、临床特征及危险因素：一项41例的横断面研究
Lupus. 2017 Oct;26(12):1304-1308. doi: 10.1177/0961203317700486. Epub 2017 Mar 29.
8
Hydroxychloroquine-Induced Erythema Multiforme.羟氯喹诱导的多形红斑
J Clin Rheumatol. 2017 Mar;23(2):127-128. doi: 10.1097/RHU.0000000000000417.
9
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Int J Mol Sci. 2016 Jul 27;17(8):1214. doi: 10.3390/ijms17081214.
10
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Pharmacogenet Genomics. 2016 May;26(5):225-34. doi: 10.1097/FPC.0000000000000211.
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