Zheng Qiaoli, Jin Na, Cheng Hao
Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Pharmacogenomics. 2024;25(14-15):569-572. doi: 10.1080/14622416.2024.2430167. Epub 2024 Nov 18.
Acute generalized exanthematous pustulosis (AGEP) is a rare drug reaction characterized by numerous pustules on an erythematous base. In some cases, hydroxychloroquine (HCQ) can cause AGEP. There is an association between HLA genes and AGEP according to pharmacogenomic studies. In this case report, we present the case of a 36-year-old female who developed HCQ-induced AGEP with HLA-typing. According to our findings, the patient had HLA-B 58:01, HLA-C 08:01, and HLA-A 02:06. A pharmacoeconomic perspective of HLA genotyping before drug prescription is shown in this result.
急性泛发性脓疱性皮病（AGEP）是一种罕见的药物反应，其特征为在红斑基础上出现大量脓疱。在某些情况下，羟氯喹（HCQ）可导致AGEP。根据药物基因组学研究，HLA基因与AGEP之间存在关联。在本病例报告中，我们呈现了一名36岁女性发生HCQ诱导的AGEP并进行HLA分型的病例。根据我们的研究结果，该患者具有HLA - B 58:01、HLA - C 08:01和HLA - A 02:06。此结果显示了在药物处方前进行HLA基因分型的药物经济学观点。
