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头孢氨苄诱发的急性泛发性脓疱性皮疹病

Cephalexin-induced acute generalized exanthematous pustulosis.

作者信息

DaCunha Matthew, Moore Sarah, Kaplan David

机构信息

University of Kansas Medical Center, Kansas City, Kansas, USA.

出版信息

Dermatol Reports. 2018 Oct 1;10(2):7686. doi: 10.4081/dr.2018.7686.

DOI:10.4081/dr.2018.7686
PMID:30464809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6207850/
Abstract

Cephalexin is a cephalosporin antibiotic that is commonly used in the treatment of infectious diseases. We report a patient exhibiting a rare adverse effect of cephalexin: drug-induced Acute Generalized Exanthematous Pustulosis (AGEP). We present this case because of the scarcity of reports associating cephalexin with AGEP in hopes that clinicians will consider AGEP in their differential diagnosis in the appropriate clinical setting.

摘要

头孢氨苄是一种常用于治疗传染病的头孢菌素类抗生素。我们报告了一名出现头孢氨苄罕见不良反应的患者：药物性急性泛发性脓疱性皮病（AGEP）。我们之所以呈现这个病例，是因为将头孢氨苄与AGEP相关联的报告较少，希望临床医生在适当的临床环境中进行鉴别诊断时会考虑到AGEP。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/6207850/42518458fa3e/dr-10-2-7686-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/6207850/61ec28f2220a/dr-10-2-7686-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/6207850/d89b3c8ce17d/dr-10-2-7686-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/6207850/42518458fa3e/dr-10-2-7686-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/6207850/61ec28f2220a/dr-10-2-7686-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/6207850/d89b3c8ce17d/dr-10-2-7686-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/6207850/42518458fa3e/dr-10-2-7686-g003.jpg

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本文引用的文献

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Case Rep Dermatol. 2017 Apr 27;9(1):135-139. doi: 10.1159/000471842. eCollection 2017 Jan-Apr.
2
Acute generalised exanthematous pustulosis (AGEP)-a potential pitfall for the acute physician.急性泛发性脓疱性皮病（AGEP）——急性科医生需警惕的潜在陷阱。
Acute Med. 2016;15(3):140-144.
3
Five-Year Retrospective Review of Acute Generalized Exanthematous Pustulosis.急性泛发性脓疱性皮病的五年回顾性研究
头孢曲松钠所致急性泛发性发疹性脓疱病
Indian J Pharmacol. 2024 Jul 1;56(4):297-298. doi: 10.4103/ijp.ijp_127_24. Epub 2024 Sep 10.
4
Electrochemical Nano-Imprinting of Trimetallic Dendritic Surface for Ultrasensitive Detection of Cephalexin in Pharmaceutical Formulations.用于超灵敏检测药物制剂中头孢氨苄的三金属树枝状表面的电化学纳米压印
Pharmaceutics. 2023 Mar 8;15(3):876. doi: 10.3390/pharmaceutics15030876.
5
Drug Triggers and Clinic of Acute Generalized Exanthematous Pustulosis (AGEP): A Literature Case Series of 297 Patients.药物引发的急性泛发性脓疱性皮病（AGEP）及其临床研究：297例患者的文献病例系列
J Clin Med. 2022 Jan 13;11(2):397. doi: 10.3390/jcm11020397.
Dermatol Res Pract. 2015;2015:260928. doi: 10.1155/2015/260928. Epub 2015 Dec 10.
4
[Acute generalized exanthematous pustulosis].[急性泛发性脓疱性皮病]
Hautarzt. 2014 May;65(5):430-5. doi: 10.1007/s00105-013-2698-7.
5
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6
Acute generalized exanthematous pustulosis: an overview of the clinical, immunological and diagnostic concepts.急性泛发性发疹性脓疱病：临床、免疫学和诊断概念概述。
Eur J Dermatol. 2010 Jul-Aug;20(4):425-33. doi: 10.1684/ejd.2010.0932. Epub 2010 Jun 14.
7
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8
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N Engl J Med. 1988 Feb 25;318(8):490-500. doi: 10.1056/NEJM198802253180806.
9
[Mechanisms of action of beta-lactam antibiotics and mechanisms of non-enzymatic resistance].β-内酰胺类抗生素的作用机制及非酶促耐药机制
Presse Med. 1986 Dec 20;15(46):2282-9.
10
Acute generalized exanthematous pustulosis. Analysis of 63 cases.急性泛发性脓疱性皮病。63例分析。
Arch Dermatol. 1991 Sep;127(9):1333-8.