College of Medicine, Shantou University, Shantou, China.
Department of Endocrinology and Metabolism, First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Front Endocrinol (Lausanne). 2024 Nov 4;15:1402369. doi: 10.3389/fendo.2024.1402369. eCollection 2024.
Oxidative stress plays a crucial role in the development and progression of hyperuricemia/gout. This study aims to explore the relationship between the Oxidative Balance Score (OBS) and hyperuricemia/gout.
The study utilized complete data from adult participants in the National Health and Nutrition Examination Survey (NHANES) spanning from 2009 to 2018. OBS, composed of scores for 20 dietary and lifestyle factors, served as the exposure variable. Multivariable linear regression model was applied to evaluate the association between OBS and uric acid (UA). Multivariable logistic regression, subgroup analyses, and restricted cubic spline (RCS) regression were conducted to explore the relationship between OBS and hyperuricemia/gout.
A total of 18,998 participants were included. In the fully adjusted model, compared to the lowest quartile, the highest quartiles of OBS, dietary OBS, and lifestyle OBS were negatively correlated with UA (β=-0.31 (-0.36,-0.25), β=-0.18 (-0.24,-0.12), and β=-0.64 (-0.69,-0.59), respectively) and hyperuricemia (OR=0.63 (0.55,0.71), OR=0.76 (0.67,0.86), OR=0.37 (0.33,0.42), respectively). Moreover, the highest quartiles of OBS and lifestyle OBS exhibited a negative correlation with gout (OR=0.72(0.58,0.91), OR=0.54 (0.43,0.67), respectively). Subgroup analyses revealed differences in the negative association between OBS and hyperuricemia concerning hypertension (p for interaction =0.002) and diabetes (p for interaction= 0.004), while gender-related disparities were observed in the negative association between OBS and gout (p for interaction =0.008). RCS analysis demonstrated a linear negative association between hyperuricemia and OBS (p for non-linearity >0.05), while gout exhibited a non-linear negative association (p for non-linearity<0.05).
The study found that a higher OBS was associated with a decreased risk of developing hyperuricemia/gout, underscoring its potential in the prevention and management of these conditions.
氧化应激在高尿酸血症/痛风的发生和发展中起着关键作用。本研究旨在探讨氧化平衡评分（OBS）与高尿酸血症/痛风之间的关系。
本研究利用 2009 年至 2018 年全国健康与营养调查（NHANES）中成年参与者的完整数据。OBS 由 20 种饮食和生活方式因素的评分组成，作为暴露变量。多变量线性回归模型用于评估 OBS 与尿酸（UA）之间的关联。多变量逻辑回归、亚组分析和限制立方样条（RCS）回归用于探讨 OBS 与高尿酸血症/痛风之间的关系。
共纳入 18998 名参与者。在完全调整模型中，与最低四分位相比，OBS、饮食 OBS 和生活方式 OBS 的最高四分位与 UA 呈负相关（β=-0.31（-0.36，-0.25）、β=-0.18（-0.24，-0.12）和β=-0.64（-0.69，-0.59））和高尿酸血症（OR=0.63（0.55，0.71）、OR=0.76（0.67，0.86）、OR=0.37（0.33，0.42））。此外，OBS 和生活方式 OBS 的最高四分位数与痛风呈负相关（OR=0.72（0.58，0.91）、OR=0.54（0.43，0.67））。亚组分析表明，OBS 与高尿酸血症之间的负相关关系在高血压（p 交互=0.002）和糖尿病（p 交互=0.004）方面存在差异，而 OBS 与痛风之间的负相关关系在性别方面存在差异（p 交互=0.008）。RCS 分析表明，高尿酸血症与 OBS 之间呈线性负相关（p 非线性>0.05），而痛风呈非线性负相关（p 非线性<0.05）。
本研究发现，较高的 OBS 与发生高尿酸血症/痛风的风险降低相关，这表明 OBS 可能在这些疾病的预防和管理中具有潜在作用。
