Bergström J, Alvestrand A, Bucht H, Gutierrez A
Clin Nephrol. 1986 Jan;25(1):1-6.
In 17 patients with chronic renal failure (creatinine clearance 12-66 ml/min) who entered a prospective study, clinical and laboratory check-ups were made once a month. This was much more frequent than during the preceding 2-year period. The progression rate of renal failure evaluated from the change with time in the reciprocal of serum creatinine and creatinine clearance, respectively, was significantly slower after entering the study than before, without any dietary intervention having been instituted. The retardation of progression was associated with improved blood pressure control. We conclude from this study that the frequency and presumably the quality of the clinical check-ups, especially with regard to control of hypertension, may favorably influence the progression of chronic renal failure, independently of the protein intake. This may have important implications for the design of randomized studies, aimed at assessing whether a lowering of protein intake may retard progression.
17例进入前瞻性研究的慢性肾衰竭患者（肌酐清除率为12 - 66 ml/min），每月进行一次临床和实验室检查。这比前两年的检查频率要高得多。分别根据血清肌酐倒数和肌酐清除率随时间的变化评估的肾衰竭进展速度，在进入研究后明显慢于之前，且未采取任何饮食干预措施。进展延缓与血压控制改善有关。我们从这项研究得出结论，临床检查的频率以及可能的质量，尤其是关于高血压的控制，可能会独立于蛋白质摄入量而对慢性肾衰竭的进展产生有利影响。这可能对旨在评估降低蛋白质摄入量是否会延缓进展的随机研究设计具有重要意义。
