Departament of Human Nutrition, University of Brasilia, Brasilia, DF, Brazil.
Gastrocirurgia de Brasilia, Brasilia, DF, Brazil.
Obes Surg. 2020 Dec;30(12):4958-4966. doi: 10.1007/s11695-020-04956-9. Epub 2020 Sep 11.
The relationship between late post-bariatric surgery weight regain and gut microbiota is not completely understood.
To analyze the profile of gut microbiota among patients with and without late weight regain after post-Roux-en-Y gastric bypass (RYGB) and to compare it with a control group (CG) comprised of obese Brazilian individuals.
This is a cross-sectional study which enrolled 34 morbidly obese women divided into 3 groups: post-Roux-en-Y gastric bypass without (RYGB_non-regain), and with weight regain (RYGB_regain) at least 5 years after surgery, and a CG of preoperative individuals. Gut microbiota was determined by metagenomic analyses.
The alpha diversity was higher in groups RYGB non-regain and RYGB regain when compared with CG (p < 0.05). Both RYGB non-regain and RYGB regain groups showed a lower abundance of the phylum Bacteroidetes when compared with CG (p < 0.01). The genera Bacteroides and SMB53 were increased in CG (p < 0.05). Group RYGB non-regain showed more abundance of the Akkermansia genus when compared with CG and group RYGB regain (p < 0.05). RYGB non-regain showed a greater abundance of the Phascolarctobacterium genus and lower of the SMB53 genus when compared with CG (p < 0.05). RYGB non-regain showed a greater abundance of the Phascolarctobacterium genus and a lower of the SMB53 genus when compared with CG (p < 0.05).
The gut microbiota of individuals which presented late weight regain after RYGB was significantly different in comparison to individuals with a successful weight loss, a finding that points towards a significant role of gut microbiota on weight loss and maintenance after surgery.
术后肥胖症患者体重反弹与肠道微生物群之间的关系尚未完全阐明。
分析罗伊氏胃旁路术后（RYGB）后出现晚期体重反弹和未出现晚期体重反弹患者的肠道微生物群特征，并与巴西肥胖个体的对照组（CG）进行比较。
这是一项横断面研究，共纳入 34 名病态肥胖女性，分为 3 组：RYGB 术后无体重反弹（RYGB_non-regain）和至少 5 年后出现体重反弹（RYGB_regain），以及术前 CG。通过宏基因组分析确定肠道微生物群。
与 CG 相比，RYGB_non-regain 和 RYGB_regain 两组的 alpha 多样性更高（p<0.05）。与 CG 相比，RYGB_non-regain 和 RYGB_regain 两组的厚壁菌门丰度均较低（p<0.01）。CG 中双歧杆菌属和 SMB53 属的丰度增加（p<0.05）。与 CG 和 RYGB_regain 组相比，RYGB_non-regain 组阿克曼氏菌属的丰度更高（p<0.05）。与 CG 相比，RYGB_non-regain 组的 Phascolarctobacterium 属丰度更高，SMB53 属丰度更低（p<0.05）。
与成功减肥的患者相比，RYGB 后出现晚期体重反弹的患者肠道微生物群明显不同，这表明肠道微生物群在手术后体重减轻和维持方面发挥着重要作用。
