Sambo Júlia, Sitoe Nádia, Nguenha Neuza, Chilaúle Jorfélia, Guambe Phath, Langa Denise, Rafael Júlio, Mudenyanga Chishamiso, Mabunda Nédio, Loquiha Osvaldo, Jani Ilesh
Instituto Nacional de Saúde, Marracuene, Maputo, Mozambique.
Clinton Health Access Initiative, Maputo, Mozambique.
Am J Trop Med Hyg. 2024 Nov 19;112(4_Suppl):46-52. doi: 10.4269/ajtmh.23-0805. Print 2025 Apr 1.
Conventional diagnostic systems struggled to meet the fluctuating demand for testing across the different waves of the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to assess the feasibility and effectiveness of the walkthrough (WT) approach in extending access to COVID-19 testing to high-risk populations traditionally underrepresented at health facilities (HFs) and to observe its impact on testing demand. An interventional study was implemented in markets (WT markets) and ports (WT ports) in Maputo City and Province, Mozambique. Demographic, epidemiological, and clinical data were collected for patients testing for COVID-19 in HFs and at WTs, and a nasal swab COVID-19 antigen rapid diagnostic test (Ag-RDT) was administered. Overall, testing rates at WTs were higher than those at HFs. At WTs, 4,452 of 4,457 participants were eligible and screened for COVID-19. Most participants were fully vaccinated for COVID-19 and had no symptoms or comorbidities (62.1% at WT markets and 87.9% at WT ports). During the baseline phase, the incidence testing rate of Ag-RDTs in intervention health facilities near the WTs was approximately one-fifth (P <0.001) of that in the control HFs located far from the WTs. In the control HFs, the incidence testing rate decreased significantly during the intervention period, whereas in intervention HFs, the incidence testing rate increased by approximately four times (P = 0.005). During times of low positivity rates and limited patient flow, the WT testing points may not yield the expected results in lowering the incidence testing rate within HFs. The WT may constitute an alternative approach to increasing the screening of infectious and noncommunicable diseases.
传统诊断系统难以满足2019冠状病毒病(COVID-19)大流行不同阶段对检测不断变化的需求。本研究旨在评估穿行式(WT)方法在扩大COVID-19检测覆盖范围至传统上在医疗机构(HFs)中代表性不足的高危人群方面的可行性和有效性,并观察其对检测需求的影响。在莫桑比克马普托市和马普托省的市场(WT市场)和港口(WT港口)开展了一项干预性研究。收集了在HFs和WTs进行COVID-19检测的患者的人口统计学、流行病学和临床数据,并进行了鼻拭子COVID-19抗原快速诊断检测(Ag-RDT)。总体而言,WTs的检测率高于HFs。在WTs,4457名参与者中有4452名符合条件并接受了COVID-19筛查。大多数参与者已完成COVID-19全程接种,且无症状或合并症(WT市场为62.1%,WT港口为87.9%)。在基线阶段,WTs附近干预医疗机构中Ag-RDT的发病率检测率约为远离WTs的对照HFs的五分之一(P<0.001)。在对照HFs中,干预期间发病率检测率显著下降,而在干预医疗机构中,发病率检测率增加了约四倍(P = 0.005)。在阳性率较低和患者流量有限时,WT检测点可能无法在降低HFs内发病率检测率方面产生预期结果。WT可能构成增加传染病和非传染性疾病筛查的一种替代方法。