Prakash Ruchika S, Shankar Anita, Tripathi Vaibhav, Yang Winson F Z, Fisher Megan, Bauer Clemens C C, Betzel Richard, Sacchet Matthew D
Department of Psychology, The Ohio State University, Columbus, Ohio; Center for Cognitive and Behavioral Brain Imaging, The Ohio State University, Columbus, Ohio.
Department of Psychology, The Ohio State University, Columbus, Ohio; Center for Cognitive and Behavioral Brain Imaging, The Ohio State University, Columbus, Ohio.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2025 Apr;10(4):350-358. doi: 10.1016/j.bpsc.2024.11.005. Epub 2024 Nov 17.
Network neuroscience is an interdisciplinary field, which can be used to understand the brain by examining the connections between its constituent elements. In recent years, the application of network neuroscience approaches to study the intricate nature of the structural and functional relationships within the human brain has yielded unique insights into its organization. In this review, we begin by defining network neuroscience and providing an overview of the common metrics that describe the topology of human structural and functional brain networks. Then, we present a detailed overview of a limited but growing body of literature that has leveraged network neuroscience metrics to demonstrate the impact of mindfulness meditation on modulating the fundamental structural and functional network properties of segregation, integration, and influence. Although preliminary, results across studies suggest that mindfulness meditation results in a shift in connector hubs, such as the anterior cingulate cortex, the thalamus, and the mid-insula. Although there is mixed evidence regarding the impact of mindfulness training on global metrics of connectivity, the default mode network exhibits reduced intraconnectivity following mindfulness training. Our review also underscores essential directions for future research, including a more comprehensive examination of mindfulness training and its potential to influence structural and functional connections at the nodal, network, and whole-brain levels. Furthermore, we emphasize the importance of open science, adoption of rigorous study designs to improve the internal validity of studies, and the inclusion of diverse samples in neuroimaging studies to comprehensively characterize the impact of mindfulness on brain organization.
网络神经科学是一个跨学科领域，它可以通过研究大脑组成元素之间的连接来理解大脑。近年来，应用网络神经科学方法来研究人类大脑内部结构和功能关系的复杂本质，已经为其组织提供了独特的见解。在这篇综述中，我们首先定义网络神经科学，并概述描述人类大脑结构和功能网络拓扑结构的常见指标。然后，我们详细概述了一小部分但不断增长的文献，这些文献利用网络神经科学指标来证明正念冥想对调节分离、整合和影响等基本结构和功能网络特性的影响。尽管是初步的，但各项研究结果表明，正念冥想会导致连接枢纽发生变化，如前扣带回皮质、丘脑和脑岛中部。尽管关于正念训练对全局连通性指标的影响存在混合证据，但默认模式网络在正念训练后表现出内部连通性降低。我们的综述还强调了未来研究的重要方向，包括更全面地考察正念训练及其在节点、网络和全脑水平上影响结构和功能连接的潜力。此外，我们强调开放科学的重要性，采用严谨的研究设计以提高研究的内部效度，以及在神经影像学研究中纳入多样化样本，以全面描述正念对大脑组织的影响。
