State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, China; Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 510005 Guangzhou, China.
Department of Nephrology, The Fifth Affiliated Hospital, Southern Medical University, 510999 Guangzhou, China.
Trends Endocrinol Metab. 2022 Sep;33(9):601-613. doi: 10.1016/j.tem.2022.06.003. Epub 2022 Jul 21.
Irisin is a muscle-secreted hormone that is generated by cleavage of membrane protein FNDC-5 (fibronectin type III domain-containing protein 5). Irisin is considered to be a mediator of exercise-induced metabolic improvements, such as browning of white adipose tissue, and is known to alleviate several chronic non-metabolic diseases. Thus, irisin may be an ideal therapeutic target for metabolic and non-metabolic diseases. However, several controversies regarding irisin have hindered its clinical translation. We review the generation, regulation (especially in exercise), and metabolic as well as therapeutic effects of irisin on metabolic and non-metabolic diseases. Furthermore, we discuss controversies regarding irisin and highlight potential future research directions.
鸢尾素是一种由膜蛋白 FNDC-5（纤连蛋白 III 型结构域蛋白 5）切割产生的肌肉分泌激素。鸢尾素被认为是运动引起的代谢改善的介质，如白色脂肪组织的褐色化，并且已知可缓解几种慢性非代谢疾病。因此，鸢尾素可能是代谢和非代谢疾病的理想治疗靶标。然而，关于鸢尾素的几个争议阻碍了其临床转化。我们综述了鸢尾素的产生、调节（特别是在运动中）以及对代谢和非代谢疾病的代谢和治疗作用。此外，我们讨论了关于鸢尾素的争议，并强调了潜在的未来研究方向。
