Tang Xiaoyan, Song Yanhua, Liang Hao, He Wenjin, Chen Zili, Yang Li, Yang Cheng, Du Rui
Department of Cardiology, General Hospital of Central Theater Command, No.627, Wuluo Road, Wuhan, 430070, Hubei, China.
Department of Obstetrics and Gynaecology, WuHan TongJi Aerospace City Hospital, No.80, Shuangliu Street, Wuhan, 430416, Hubei, China.
Sci Rep. 2024 Nov 19;14(1):28667. doi: 10.1038/s41598-024-80231-6.
Urinary incontinence (UI) in females is a prevailing condition that affects individuals across various age groups and is not limited to older females. The presence of serum alpha-Klotho (α-klotho) serves as a reliable biomarker to indicate the effects of antiaging. Nevertheless, the scientific research on the association between α-klotho and UI remains limited. Therefore, the purpose of this study is to investigate and evaluate the connection between α-klotho levels and the UI among females in the US. We utilized data from the National Health and Nutrition Examination Survey 2007-2016 to investigate the potential connection between α-klotho levels and the UI among females aged 40 to 79. Weighted linear regression models and sensitivity tests were conducted to explore the correlation. 2628 females were involved in this study, representing 22,492,348 non-institutionalized residents in the US. The mean age was 53.9 ± 0.2 years and the mean level of α-klotho was 873.0 ± 8.9 pg/mL. After adjusting for relevant covariables, weighted linear regression models revealed that individuals with severe UI exhibited significantly lower serum α-klotho levels (β = - 100.66; 95% CI: - 156.31, - 45.01; P < 0.001) than those without UI. Furthermore, in stratified analyses, the correlation was not significant in individuals with normal weight, cardiovascular disease, or chronic kidney disease. We did not find a significant association between the type of UI and α-klotho levels. In the NHANES data from 2007 to 2016, a noteworthy inverse relationship was noted between α-klotho levels and the severity of UI among females aged 40 to 79.
女性尿失禁（UI）是一种普遍存在的疾病，影响各个年龄段的个体，并不局限于老年女性。血清α-klotho（α-kl）的存在是一种可靠的生物标志物，可指示抗衰老的效果。然而，关于α-klotho与尿失禁之间关联的科学研究仍然有限。因此，本研究的目的是调查和评估美国女性中α-klotho水平与尿失禁之间的联系。我们利用2007 - 2016年国家健康与营养检查调查（NHANES）的数据，调查40至79岁女性中α-klotho水平与尿失禁之间的潜在联系。进行加权线性回归模型和敏感性测试以探索相关性。2628名女性参与了本研究，代表了美国22492348名非机构化居民。平均年龄为53.9±0.2岁，α-klotho的平均水平为873.0±8.9 pg/mL。在调整相关协变量后，加权线性回归模型显示，重度尿失禁患者的血清α-klotho水平（β = -100.66；95% CI：-156.31，-45.01；P < 0.001）显著低于无尿失禁者。此外，在分层分析中，体重正常、患有心血管疾病或慢性肾病的个体中，这种相关性不显著。我们未发现尿失禁类型与α-klotho水平之间存在显著关联。在2007年至2016年的NHANES数据中，40至79岁女性的α-klotho水平与尿失禁严重程度之间存在显著的负相关关系。
