Du Rui, Tang Xiaoyan, Yang Cheng, Shi Jinhu, Lai Yuchen, Ding Shifang, Huang Wei
Department of Ultrasound, General Hospital of Central Theater Command, No.627, Wuluo Road, Wuhan 430070, Hubei, China.
Department of Cardiology, General Hospital of Central Theater Command, No.627, Wuluo Road, Wuhan 430070, Hubei, China.
Heliyon. 2024 Sep 24;10(19):e38298. doi: 10.1016/j.heliyon.2024.e38298. eCollection 2024 Oct 15.
α-Klotho is a molecule associated with aging and several diseases. Previous studies have reported decreased levels of serum α-Klotho (SαKl) in smokers compared to never smokers. Interestingly, we also found the SαKl level could partly recover in those who quit smoking. The objective of this study was to investigate SαKl levels in the US population who quit smoking for a certain period.
A total of 9268 participants, ranging in age from 40 to 79 years were enrolled in this cross-sectional study, 37.04 % were identified as former smoker. Data from the NHANES conducted between 2007 and 2016 were utilized for analysis. The association between the period of smoking cessation and SαKl levels was evaluated through multivariate linear regression models. Additionally, a detailed analysis stratified by key clinical factors was performed.
The mean level of SαKl among the former smoker was 827.41 pg/mL. After full adjustment, the SαKl level increased over time after smoking cessation, with an increase of 1.20 pg/ml per year of abstinence ( = 0.005). The linear correlation persists regardless of the duration of the smoking habit before quitting. In the stratified analysis, a positive correlation was observed between duration of smoking cessation and SαKl levels in individuals aged 60-79 years, females, normal weight individuals, those involved in moderate or vigorous physical activity, and those with a history of cancer (all 0.05).
This study showed a positive association between the duration of smoking cessation and SαKl levels in former smokers. Prolonged abstinence may contribute to increased SαKl levels which may protect people against aging-related diseases.
α-klotho是一种与衰老及多种疾病相关的分子。既往研究报道，与从不吸烟者相比，吸烟者血清α-klotho（SαKl）水平降低。有趣的是，我们还发现戒烟者的SαKl水平可部分恢复。本研究的目的是调查美国特定时间段戒烟人群的SαKl水平。
本横断面研究共纳入9268名年龄在40至79岁之间的参与者，其中37.04%为既往吸烟者。利用2007年至2016年期间美国国家健康与营养检查调查（NHANES）的数据进行分析。通过多变量线性回归模型评估戒烟时间与SαKl水平之间的关联。此外，还按关键临床因素进行了详细的分层分析。
既往吸烟者的SαKl平均水平为827.41 pg/mL。经过全面调整后，戒烟后SαKl水平随时间升高，每年戒烟增加1.20 pg/ml（P = 0.005）。无论戒烟前吸烟习惯的持续时间如何，线性相关性均持续存在。在分层分析中，60至79岁个体、女性、体重正常个体、参与中度或剧烈体力活动的个体以及有癌症病史的个体中，戒烟时间与SαKl水平呈正相关（均P<0.05）。
本研究显示既往吸烟者的戒烟时间与SαKl水平呈正相关。长期戒烟可能有助于提高SαKl水平，这可能保护人们预防与衰老相关的疾病。
