Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Sci Rep. 2024 Nov 19;14(1):28618. doi: 10.1038/s41598-024-80238-z.
Polycystic ovary syndrome (PCOS) is one of the most prevalent obesity-related diseases in women of reproductive age. Linkage between diet and PCOS are still controversial. Dietary obesity prevention score (DOS) is one of the new indicators of diet evaluation which have been previously linked to obesity. To the best of our knowledge, this study was the first to investigate the relationship between DOS and PCOS. In this case-control study, 100 newly diagnosed women with PCOS and 100 age-matched women without PCOS were assayed from clinics affiliated to Kashan university of medical sciences, Kashan, Iran. A validated semi-quantitative food frequency questionnaire was used to evaluate food intakes. DOS was calculated based on previous published guideline. Anthropometric measurements were carefully measured by a trained nutritionist. A 10-houres fasting plasma blood sample was collected for all participants. Fasting blood sugar (FBS), triglyceride (TG), total cholesterol (CHOL), High density lipoprotein (HDL), Low density lipoprotein (LDL) and C - reactive protein (CRP) were measured based on laboratory methods. The mean age and BMI of study participants was 23.6 year and 24.9 kg/m respectively. After adjustment for potential confounders, adherence to DOS score was inversely associated with CRP levels. People in the top tertile of DOS had lower CRP level compared to people in the bottom tertile (3.71 compared to 4.48 mg/dl) (P = 0.04). In addition, participant in the top tertile of DOS had marginally significant higher level of FBS compared to participants in the bottom tertile (92.3 vs. 88.9 mg/dl, P = 0.051). After adjustment for all confounding factors people in the highest tertile of DOS had a 46% non-significant lower odds for PCOS compared to people in the lowest tertile (95% CI: 0.23-1.25; P-trend = 0.15). In the present study, an inverse significant association was seen between adherence to DOS and inflammation. However, no significant relationship was observed between DOS and odds of having PCOS. Further longitudinal studies are suggested to investigate the association between DOS and PCOS.
多囊卵巢综合征（PCOS）是育龄妇女中最常见的肥胖相关疾病之一。饮食与 PCOS 之间的联系仍存在争议。膳食肥胖预防评分（DOS）是饮食评估的新指标之一，此前已与肥胖有关。据我们所知，这项研究首次调查了 DOS 与 PCOS 之间的关系。在这项病例对照研究中，我们从伊朗卡尚医科大学附属医院招募了 100 名新诊断的 PCOS 女性和 100 名年龄匹配的非 PCOS 女性。使用经过验证的半定量食物频率问卷评估食物摄入量。DOS 是根据以前发表的指南计算的。由经过培训的营养师仔细测量人体测量学指标。所有参与者均采集禁食 10 小时的血浆血样。根据实验室方法测量空腹血糖（FBS）、甘油三酯（TG）、总胆固醇（CHOL）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和 C 反应蛋白（CRP）。研究参与者的平均年龄和 BMI 分别为 23.6 岁和 24.9kg/m2。在校正潜在混杂因素后，DOS 评分的依从性与 CRP 水平呈负相关。DOS 评分最高 tertile 的人 CRP 水平低于最低 tertile（3.71 与 4.48mg/dl）（P=0.04）。此外，DOS 评分最高 tertile 的参与者 FBS 水平略高于最低 tertile（92.3 与 88.9mg/dl，P=0.051）。在校正所有混杂因素后，DOS 评分最高 tertile 的人患 PCOS 的几率比最低 tertile 的人低 46%（95%CI：0.23-1.25；P 趋势=0.15）。在本研究中，我们发现 DOS 依从性与炎症之间呈显著负相关。然而，DOS 与 PCOS 发生几率之间没有显著关系。建议进行进一步的纵向研究，以调查 DOS 与 PCOS 之间的关系。
