咖啡因摄入量与美国年轻和中年成年人的肌肉量呈非线性相关。
Caffeine intake is nonlinearly associated with muscle mass in young and middle-aged US adults.
机构信息
Metabolic Disease Center, Department of Endocrinology and Metabolism, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China.
The Third People's Hospital of Deqing, Deqing Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China.
出版信息
BMC Musculoskelet Disord. 2024 Nov 19;25(1):929. doi: 10.1186/s12891-024-08063-z.
BACKGROUND
Recent studies have indicated that coffee consumption is inversely correlated with sarcopenia in the elderly population. Data regarding the association between caffeine intake and muscle mass in young adults are scarce.
OBJECTIVE
We aimed to investigate how dietary caffeine correlates with muscle mass and sarcopenia in the young and middle-aged people.
METHODS
We performed a cross-sectional study utilizing data from NHANES. Muscle mass was evaluated using DXA and caffeine intake was derived from 24-h dietary recalls. Multivariable regression analysis was adopted to explore association between caffeine and sarcopenia. Restricted cubic spline analysis was conducted to investigate dose-response effect of dietary caffeine on muscle mass. Mediation effect of high-sensitivity C reactive protein was examined by mediation analysis.
RESULTS
A total of 9116 adults aged from 20 to 59 years old were included. Higher ingestion of caffeine was not associated with sarcopenia. Association between dietary caffeine and muscle mass was found to be W-shaped in males and U-shaped in young females, wherein mediation effect of hs-CRP was not discovered.
CONCLUSIONS
Caffeine consumption is associated with muscle mass in a nonlinear pattern. ASMI peaks at a daily caffeine intake of 1.23 mg/kg in young adults, while 0.64-1.49 mg/kg is recommended for middle-aged men.
背景
最近的研究表明，咖啡的摄入与老年人的肌肉减少症呈负相关。关于年轻人咖啡因摄入量与肌肉质量之间的关系的数据很少。
目的
我们旨在研究饮食中的咖啡因与年轻人和中年人肌肉质量和肌肉减少症之间的相关性。
方法
我们利用 NHANES 的数据进行了一项横断面研究。使用 DXA 评估肌肉质量，从 24 小时膳食回忆中得出咖啡因摄入量。采用多变量回归分析来探讨咖啡因与肌肉减少症之间的关联。采用限制性立方样条分析来探讨饮食咖啡因对肌肉质量的剂量反应效应。通过中介分析检验高敏 C 反应蛋白的中介效应。
结果
共纳入 9116 名 20 至 59 岁的成年人。较高的咖啡因摄入与肌肉减少症无关。男性中饮食咖啡因与肌肉质量之间呈 W 型相关，年轻女性中呈 U 型相关，hs-CRP 的中介效应未发现。
结论
咖啡因的摄入与肌肉质量呈非线性相关。在年轻成年人中，每日咖啡因摄入量达到 1.23mg/kg 时 ASMI 达到峰值，而中年男性则推荐摄入 0.64-1.49mg/kg。
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