Raphaël Colette, Remington Gary, Agid Ofer
Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Focus (Am Psychiatr Publ). 2024 Oct;22(4):492-494. doi: 10.1176/appi.focus.20240007. Epub 2024 Oct 15.
is defined as an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m with or without kidney damage. Creatinine, which is found in serum and urine, is a common biomarker to estimate renal function and is used in most eGFR equations. Renal impairment can decrease or increase drug effects, necessitating therapeutic adjustments. Increased effect is related to drug accumulation that leads to increased elimination time and potential toxicity. eGFR plays a crucial role in drug dosing, particularly for renally excreted medications. However, the lack of recognition of pre-existing renal impairment and the incorrect interpretation of eGFR equations remain challenges. This case report explores the significance of eGFR in patients with psychiatric conditions, especially in the context of long-acting antipsychotic drug dosing.
定义为估算肾小球滤过率（eGFR）<60 ml/min/1.73 m²，伴有或不伴有肾损伤。血清和尿液中存在的肌酐是评估肾功能的常见生物标志物，大多数eGFR方程中都使用它。肾功能损害可降低或增加药物疗效，因此需要调整治疗方案。疗效增加与药物蓄积有关，这会导致消除时间延长和潜在毒性。eGFR在药物剂量确定中起着关键作用，尤其是对于经肾脏排泄的药物。然而，对既往存在的肾功能损害缺乏认识以及对eGFR方程的错误解读仍然是挑战。本病例报告探讨了eGFR在精神疾病患者中的意义，特别是在长效抗精神病药物给药的背景下。
