Bonuccelli U, Murialdo G, Rossi G, Bonura M L, Polleri A, Murri L
Epilepsia. 1986 Mar-Apr;27(2):142-8. doi: 10.1111/j.1528-1157.1986.tb03517.x.
Circulating basal prolactin (PRL) levels were evaluated in 126 subjects of both sexes with partial or generalized epilepsy, who were treated with phenobarbital (PB) alone or in combination with either phenytoin or benzodiazepines. A significant increase in PRL levels was observed in male, but not in female, patients compared with a sex- and age-matched healthy volunteer group. Circadian PRL secretion, studied in six male epileptic patients on PB monotherapy and in nine normal subjects, showed comparable 24-h PRL mean values and a preserved PRL surge during the night in both groups; however, a statistically significant additional peak was found in male epileptic subjects during the late afternoon. The cosinor analysis of the data, used to evaluate PRL rhythmicity, showed a disruption of the 24-h periodicity in epileptic subjects, while the 12-h periodicity was maintained. These results indicate that central and/or peripheral mechanisms involved in PRL secretion control are more sensitive to PB alone or in combination with other antiepileptic drugs in male than in female subjects. However, the changes of PRL secretion we found were small and unrelated to the different clinical conditions.
对126例患有部分性或全身性癫痫的男女患者的循环基础催乳素（PRL）水平进行了评估，这些患者单独使用苯巴比妥（PB）或与苯妥英或苯二氮䓬联合使用。与性别和年龄匹配的健康志愿者组相比，男性患者的PRL水平显著升高，而女性患者则没有。在6例接受PB单一疗法的男性癫痫患者和9例正常受试者中研究了PRL的昼夜分泌，结果显示两组的24小时PRL平均值相当，且夜间PRL均有升高；然而，在男性癫痫患者的下午晚些时候发现了一个具有统计学意义的额外峰值。用于评估PRL节律性的数据的余弦分析显示，癫痫患者的24小时周期性受到破坏，而12小时周期性得以维持。这些结果表明，与女性受试者相比，参与PRL分泌控制的中枢和/或外周机制对单独使用PB或与其他抗癫痫药物联合使用时，男性更为敏感。然而，我们发现的PRL分泌变化很小，且与不同的临床情况无关。
