Krivoshlykova M S, Bobyntsev I I, Vorvul A O, Medvedeva O A, Azarova Iu E
Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
Bull Exp Biol Med. 2024 Nov;178(1):7-10. doi: 10.1007/s10517-024-06273-y. Epub 2024 Nov 20.
It was found that 28-day immobilization stress in male Wistar rats leads to significant increase in the serum concentrations of proinflammatory cytokines IL-1β, IL-6, IFNγ, and monocyte chemoattractant protein-1 (MCP-1) and a decrease in the content of anti-inflammatory IL-10, as well as the ratio IL-1β/IL-10, IL-6/IL-10, and IFNγ/IL-10 compared to non-stressed animals. Administration of the heptapeptide tuftsin-Pro-Gly-Pro produced a corrective effect on cytokine concentrations under stress conditions: at a dose of 750 μg/kg, the peptide decreased the concentrations of IL-1β, IFNγ, and MCP-1 and cytokine ratios (IL-1β/IL-10 and IFNγ/IL-10), while at a dose of 250 μg/kg, it increased IL-10 levels and decreased IL-6/IL-10 and IFNγ/IL-10 ratios.
研究发现，雄性Wistar大鼠28天的制动应激导致促炎细胞因子IL-1β、IL-6、IFNγ和单核细胞趋化蛋白-1（MCP-1）的血清浓度显著升高，抗炎性IL-10含量降低，以及与非应激动物相比IL-1β/IL-10、IL-6/IL-10和IFNγ/IL-10的比值降低。七肽促吞噬素-Pro-Gly-Pro的给药对应激条件下的细胞因子浓度产生了纠正作用：在750μg/kg的剂量下，该肽降低了IL-1β、IFNγ和MCP-1的浓度以及细胞因子比值（IL-1β/IL-10和IFNγ/IL-10），而在250μg/kg的剂量下，它提高了IL-10水平并降低了IL-6/IL-10和IFNγ/IL-10的比值。
