Salvadori B, Cusumano F, De Lellis R
Eur J Surg Oncol. 1986 Mar;12(1):47-51.
Eight cases of malignant lymphomas of the breast were considered. The age of the patients ranged from 26 to 57 years. All the cases were staged according to the Ann Arbor classification system; the distribution was 2 Ie, 2 IIe, 1 IIIe and 3 IVe. Surgery was limited to excisional biopsy in all patients, one of whom had been operated on elsewhere. Six patients had radiotherapy following limited surgery. All of them received chemotherapy. The treatment resulted in complete local control of the disease in all cases and only 2 patients died from disseminated disease. Six patients were alive and free of disease from 34 to 84 months after the diagnosis. Our experience and analysis of the literature allow us to conclude that the role of surgery in the diagnosis and treatment of malignant lymphomas with breast involvement should be limited to removal of the nodule, when possible, or to incisional biopsy in the case of massive involvement of the breast. In effect, aggressive surgery with a radical aim is not presently justified; in contrast, systemic chemotherapy should always be administered.
研究纳入了8例乳腺恶性淋巴瘤患者。患者年龄在26至57岁之间。所有病例均按照Ann Arbor分类系统进行分期;分布情况为2例Ie期、2例IIe期、1例IIIe期和3例IVe期。所有患者的手术均限于切除活检,其中1例患者曾在其他地方接受过手术。6例患者在有限手术之后接受了放疗。所有患者均接受了化疗。治疗使所有病例的疾病实现了完全局部控制,仅有2例患者死于播散性疾病。6例患者在诊断后34至84个月存活且无疾病。我们的经验及文献分析使我们得出结论,手术在伴有乳腺受累的恶性淋巴瘤的诊断和治疗中的作用应限于在可能的情况下切除结节,或在乳腺广泛受累时进行切开活检。实际上,目前尚无理由进行以根治为目的的激进手术;相反,应始终给予全身化疗。