Department of Orthopaedic Surgery, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Department of Pathology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan.
World J Surg Oncol. 2024 Nov 20;22(1):307. doi: 10.1186/s12957-024-03583-3.
This correspondence addresses the article published by Nie et al. titled "Primary extraskeletal osteosarcoma of sigmoid mesocolon: a case report and a review of the literature". Their report highlighted an extremely rare case of extraskeletal osteosarcoma (EO) in the sigmoid mesocolon that was diagnosed through imaging and histopathological findings. Diagnosing EO has certain challenges; one of them being the lack of characteristic image findings of EO and the other being the lack of appropriate immunohistochemical (IHC) markers in the histopathological findings. Recently, special AT-rich sequence-binding protein 2 (SATB2) has been proposed as an IHC marker for osteoblastic differentiation; however, it has low specificity. Some cases of EO may show findings such as mouse double minute protein 2 expression and deletion of histone H3 lysine 27 trimethylation (H3K27me3), which are similar to those of other soft tissue sarcomas. Therefore, it is essential to consider other soft tissue sarcomas, especially dedifferentiated liposarcoma, before the accurate diagnosis of EO.
这封通信函针对的是聂等人发表的题为“乙状结肠系膜原发性骨外骨肉瘤：病例报告及文献复习”的文章。他们的报告强调了乙状结肠系膜骨外骨肉瘤（EO）的一个极其罕见的病例，该病例通过影像学和组织病理学发现进行了诊断。诊断 EO 具有一定的挑战性，其中之一是缺乏 EO 的特征性图像发现，另一个是在组织病理学发现中缺乏适当的免疫组织化学（IHC）标志物。最近，富含特殊 AT 序列结合蛋白 2（SATB2）被提议作为成骨分化的 IHC 标志物，但特异性较低。一些 EO 病例可能表现出类似其他软组织肉瘤的特征，如鼠双微体蛋白 2 表达和组蛋白 H3 赖氨酸 27 三甲基化（H3K27me3）缺失。因此，在准确诊断 EO 之前，必须考虑其他软组织肉瘤，特别是去分化脂肪肉瘤。
