N-亚硝基-N-丁基-（4-羟基丁基）胺暴露对次氮基三乙酸三钠引起的矿物质代谢变化的影响。

Effect of N-nitroso-n-butyl-(4-hydroxybutyl)amine exposure on the changes in mineral disposition caused by trisodium nitrilotriacetate.

作者信息

Anderson R L, Kanerva R L, Lefever F R, Francis W R

出版信息

Food Chem Toxicol. 1986 Mar;24(3):229-35. doi: 10.1016/0278-6915(86)90233-4.

Abstract

Male Fischer 344 rats were used to determine effect of consumption of 0.5% N-nitroso-n-butyl-(4-hydroxybutyl)amine (BNN) in the drinking-water for 2 wk on the response to 0.02, 0.2 and 2.0% trisodium nitrilotriacetate (Na3 NTA . H2O) in the diet in terms of urinary mineral excretion, bladder mass and bladder mineral concentrations. The primary objective of the study was to determine whether exposure of rats to an initiating dose of a bladder carcinogen (BBN) alters the threshold dose of Na3NTA . H2O required to alter urinary or bladder mineral concentrations or the dose-response to NTA. Such alterations are considered to be necessary precursors for changes in bladder morphology in rats fed NTA in chronic toxicity studies (Anderson, Bishop & Campbell, CRC Crit. Rev. Toxicol. 1985, 15, 1). The results demonstrated that BBN exposure caused an increase in bladder mass and bladder-tissue Zn concentration. However, BBN pretreatment did not have any effect on Na3NTA . H2O metabolism, the threshold dose of Na3NTA . H2O required to attain the necessary conditions for induction of bladder toxicity by NTA, or the dose-response relationships for NTA's effects on any parameter examined. From these data, it is concluded that it is unlikely that NTA would show a different threshold or dose-response for bladder tumour promotion than for its tumorigenicity at this site, which has been demonstrated previously (National Cancer Institute, DHEW Publication No. (NIH) 77-806, 1977).

摘要

雄性Fischer 344大鼠用于确定饮用水中0.5%的N-亚硝基-N-丁基-（4-羟基丁基）胺（BNN）摄入2周对饮食中0.02%、0.2%和2.0%次氮基三乙酸三钠（Na3NTA·H2O）反应的影响，具体涉及尿矿物质排泄、膀胱质量和膀胱矿物质浓度。该研究的主要目的是确定大鼠接触起始剂量的膀胱致癌物（BBN）是否会改变改变尿或膀胱矿物质浓度所需的Na3NTA·H2O阈值剂量，或对NTA的剂量反应。在慢性毒性研究中，这种改变被认为是喂食NTA的大鼠膀胱形态变化的必要前体（Anderson、Bishop和Campbell，《CRC批判性评论毒理学》，1985年，第15卷，第1期）。结果表明，BBN暴露导致膀胱质量和膀胱组织锌浓度增加。然而，BBN预处理对Na3NTA·H2O代谢、NTA诱导膀胱毒性所需的Na3NTA·H2O阈值剂量，或NTA对任何检测参数的影响的剂量反应关系均无任何影响。根据这些数据得出结论，NTA在膀胱肿瘤促进方面不太可能表现出与该部位致癌性不同的阈值或剂量反应，这一点此前已有证明（美国国家癌症研究所，DHEW出版物编号（NIH）77 - 806，1977年）。