Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Beijing University of Chinese Medicine, Beijing, China.
Ren Fail. 2024 Dec;46(2):2423846. doi: 10.1080/0886022X.2024.2423846. Epub 2024 Nov 21.
Macrophages play a variety of widely concerned roles in the process of chronic kidney disease (CKD). To further understand the research hotspots and development trends regarding the relationship between macrophages and CKD, the role of macrophages in the occurrence and progression of CKD was summarized by bibliometrics in this study.
We collected the studies relevant the role of macrophages in CKD from the Web of Science Core Collection, which included 1332 relevant studies from Jan 1st, 2004 to Jul 6th, 2023 in WoSCC. CiteSpace, biblioshiny in R, VOSviewer and SCImago Graphica Beta were used for bibliometric analysis and visualization.
Monash University from Australia is the most productive institution, while China and the USA are most productive countries. Anders HJ is the most cited author. In terms of the number of co-citations, the top one was "Macrophages: versatile players in renal inflammation and fibrosis" by Patrick Ming-Kuen Tang, published in Nature Reviews Nephrology in 2019. Important keywords of this research topic include inflammation, dendritic cell, oxidative stress, NF-κB, tgf-beta, interstitial fibrosis, glomerulonephritis, diabetic nephropathy. Future research hotspots may include molecular mechanism, acute kidney injury, macrophage polarization, kidney fibrosis.
This study provides a systematic review of the role of macrophages in CKD and speculates that future research hotspots. Previous studies have focused on the immune function of macrophages and atypia, and metabolic factors (especially iron metabolism within macrophages) have attracted the attention of researchers in recent years and are the forefront of recent research.
巨噬细胞在慢性肾脏病（CKD）的发生发展过程中发挥着多种广泛关注的作用。为了进一步了解巨噬细胞与 CKD 关系的研究热点和发展趋势，本研究采用文献计量学方法总结了巨噬细胞在 CKD 发生和进展中的作用。
我们从 Web of Science 核心合集（WoSCC）中收集了巨噬细胞在 CKD 中的作用相关的研究，其中包括 2004 年 1 月 1 日至 2023 年 7 月 6 日在 WoSCC 中收录的 1332 项相关研究。使用 CiteSpace、R 中的 biblioshiny、VOSviewer 和 SCImago Graphica Beta 进行文献计量分析和可视化。
澳大利亚莫纳什大学是最具生产力的机构，而中国和美国是最具生产力的国家。Anders HJ 是被引频次最高的作者。就共被引次数而言，排名第一的是 2019 年由 Patrick Ming-Kuen Tang 发表在《自然评论肾病学》上的“巨噬细胞：肾脏炎症和纤维化中的多功能扮演者”。该研究主题的重要关键词包括炎症、树突状细胞、氧化应激、NF-κB、tgf-β、间质纤维化、肾小球肾炎、糖尿病肾病。未来的研究热点可能包括分子机制、急性肾损伤、巨噬细胞极化、肾纤维化。
本研究系统地综述了巨噬细胞在 CKD 中的作用，并推测了未来的研究热点。以前的研究主要集中在巨噬细胞的免疫功能和表型上，近年来代谢因素（尤其是巨噬细胞内的铁代谢）引起了研究人员的关注，成为了近期研究的前沿。
