Bouchiba Mustapha, Turki Mouna, Zarzissi Slim, Zghal Firas, Trabelsi Omar, Rebai Haithem, Bouzid Mohamed Amine
Research Laboratory: Education, Motricité, Sport et Santé, EM2S, LR19JS01, High Institute of Sport and Physical Education, University of Sfax, Tunisia; Laboratoire Hypoxie & Poumon, UMR INSERM U1272, Université Sorbonne Paris Nord, Bobigny, France.
Laboratory of Biochemistry, CHU Habib Bourguiba, Sfax University, Tunisia.
J Sci Med Sport. 2025 Mar;28(3):189-197. doi: 10.1016/j.jsams.2024.11.002. Epub 2024 Nov 7.
This study aimed to investigate the impact of acute acetaminophen ingestion on the responses of neuromuscular function, biomarkers of muscle damage, and physical performance during the 72-hour recovery period following simulated soccer match-play.
The study followed a crossover randomized, double-blind, placebo-controlled trial design.
During the two experimental sessions, thirteen semi-professional male soccer players completed a 90-minute simulated soccer match, 60 min after oral ingestion of 1 g acetaminophen or placebo. Maximal voluntary contraction and twitch responses of the knee extensor muscles, elicited through electrical femoral nerve stimulation, were utilized to evaluate both peripheral fatigue (potentiated twitch force, Q) and central fatigue (voluntary activation). Performance was assessed through countermovement jump and 20 m sprint tests. Creatine kinase and lactate dehydrogenase were also measured.
Smaller reductions were observed in maximal voluntary contraction (-13.3 ± 7.5 % vs. -24.7 ± 11.1 %) and voluntary activation (-3.8 ± 4.4 % vs. -12.9 ± 5.4 %) in the acetaminophen compared to the placebo condition immediately after simulated soccer match-play (p < 0.05). Afterward, these parameters were recovered 24 h earlier in the acetaminophen session compared to the placebo session. Furthermore, the 20 m sprint performance was significantly better throughout the recovery period in the acetaminophen session compared to the placebo session.
The findings of this study showed that acute ingestion of 1 g of acetaminophen (1 h before exercise) attenuated the decrease in maximal voluntary contraction and voluntary activation levels after exercise, as well as improved 20 m sprint performance.
本研究旨在调查在模拟足球比赛后的72小时恢复期内，急性摄入对乙酰氨基酚对神经肌肉功能反应、肌肉损伤生物标志物及身体表现的影响。
本研究采用交叉随机、双盲、安慰剂对照试验设计。
在两个实验阶段，13名半职业男性足球运动员在口服1g对乙酰氨基酚或安慰剂60分钟后，完成了一场90分钟的模拟足球比赛。通过股神经电刺激诱发的股四头肌最大自主收缩和抽搐反应，用于评估外周疲劳（增强抽搐力，Q）和中枢疲劳（自主激活）。通过纵跳和20米短跑测试评估身体表现。同时还测量了肌酸激酶和乳酸脱氢酶。
与安慰剂组相比，在模拟足球比赛结束后立即服用对乙酰氨基酚组的最大自主收缩（-13.3±7.5%对-24.7±11.1%）和自主激活（-3.8±4.4%对-12.9±5.4%）的下降幅度较小（p<0.05）。此后，与安慰剂组相比，对乙酰氨基酚组的这些参数提前24小时恢复。此外，在整个恢复期内，对乙酰氨基酚组的20米短跑成绩明显优于安慰剂组。
本研究结果表明，急性摄入1g对乙酰氨基酚（运动前1小时）可减轻运动后最大自主收缩和自主激活水平的下降，并改善20米短跑成绩。
