Fusagawa Hiroyori, Youn Alex, Wilkerson Elyse, Pandya Nirav, Feeley Brian T
Department of Orthopaedic Surgery, University of California-San Francisco, 1500 Owens Street, San Francisco, CA, 94158, USA.
School of Medicine, University of California-San Francisco, 505 Parnassus Ave MU 320W, San Francisco, CA, 94143, USA.
Curr Rev Musculoskelet Med. 2025 Feb;18(2):39-47. doi: 10.1007/s12178-024-09932-9. Epub 2024 Nov 22.
The physical health impacts of microplastics have received increasing attention in recent years. However, limited data impedes a full understanding of the internal exposure to microplastics, especially concerning the musculoskeletal system. The purpose of this review is to summarize the recent literature regarding the effects of microplastics on the musculoskeletal system.
Microplastics have been shown to cause abnormal endochondral ossification and disrupt the normal function of pre-osteoblasts, osteocyte-like cells, and pre-osteoclasts through gene mutations, endoplasmic reticulum stress induction, and reduced autophagosome formation in bone growth areas. Although there are few reports on their effects on muscle, it has been noted that microplastics inhibit energy and lipid metabolism, decrease type I muscle fiber density, impair muscle angiogenesis, cause muscle atrophy, and increase lipid deposition. Only a few recent studies have shown that microplastics interfere with the normal function of bone growth-related cells and reduce muscle mass and quality. This review underscores the need for further research into other parts of the musculoskeletal system and studies using human tissues at the disease level.
近年来，微塑料对身体健康的影响受到了越来越多的关注。然而，数据有限阻碍了我们对微塑料内部暴露情况的全面了解，尤其是在肌肉骨骼系统方面。本综述的目的是总结近期关于微塑料对肌肉骨骼系统影响的文献。
微塑料已被证明会导致软骨内骨化异常，并通过基因突变、诱导内质网应激以及减少骨生长区域自噬体的形成，扰乱前成骨细胞、类骨细胞和前破骨细胞的正常功能。尽管关于它们对肌肉影响的报道很少，但已经注意到微塑料会抑制能量和脂质代谢、降低I型肌纤维密度、损害肌肉血管生成、导致肌肉萎缩并增加脂质沉积。最近只有少数研究表明微塑料会干扰与骨生长相关细胞的正常功能，并减少肌肉质量和质量。本综述强调需要对肌肉骨骼系统的其他部位进行进一步研究，并在疾病水平上使用人体组织进行研究。
