Eide T J, Nielsen K, Solberg S
Institute of Medical Biology, University of Tromsøo, Norway.
Acta Pathol Microbiol Immunol Scand A. 1987 Nov;95(6):365-9. doi: 10.1111/j.1699-0463.1987.tb00053_95a.x.
In a study of 41 surgically removed colorectal adenomas of unselected size, the dysplasia was graded as mild in 9, as moderate in 22, and severe in 10 cases. Twenty-four of the lesions were classified as tubular adenomas and 17 as tubulo-villous. The presence of O-acylated sialic mucin was for each of the adenomas assessed as normal (19 cases), intermediate (13 cases) or absent (9 cases). The absence of O-acylated mucin was in the present study found to be highly predictive for severe dysplasia (89%). The morphometric measurements of epithelial structures showed that nuclear shape factor and nuclear stratification index were most significantly related to the grades of dysplasia. In a multivariate analysis, the grading of O-cylated sialic mucin most significantly contributed to the grade of dysplasia, and to a lesser degree, nuclear shape factor and nuclear stratification index. The presence of villous elements and the size of the adenomas had no independent influence on the grade of dysplasia in this statistical analysis.
在一项对41例未经选择大小的手术切除大肠腺瘤的研究中，发育异常程度为轻度的有9例，中度的有22例，重度的有10例。其中24个病变分类为管状腺瘤，17个为管状绒毛状腺瘤。对每个腺瘤的O-酰化唾液酸粘蛋白的存在情况评估为正常（19例）、中等（13例）或缺失（9例）。在本研究中发现，O-酰化粘蛋白的缺失对重度发育异常具有高度预测性（89%）。上皮结构的形态测量显示，核形状因子和核分层指数与发育异常程度的相关性最为显著。在多变量分析中，O-酰化唾液酸粘蛋白的分级对发育异常程度的贡献最为显著，其次是核形状因子和核分层指数。在该统计分析中，绒毛成分的存在和腺瘤大小对发育异常程度没有独立影响。
