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含虫草素的北虫草提取物对脂肪细胞脂肪生成和脂肪分解的影响。

Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes.

作者信息

Kusama Kazuya, Oka Kodai, Yashiro Yumi, Yoshida Kanoko, Miyaoka Hiroaki, Tamura Kazuhiro

机构信息

Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Japan.

Department of Biomolecular Organic Chemistry, Tokyo University of Pharmacy and Life Sciences, Japan.

出版信息

FEBS Open Bio. 2025 Feb;15(2):335-345. doi: 10.1002/2211-5463.13930. Epub 2024 Nov 21.

DOI:10.1002/2211-5463.13930
PMID:39572891
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11788751/
Abstract

Obesity, a global health concern, results from an energy imbalance leading to lipid accumulation. In the present study, Cordyceps militaris extract (CM) and its primary component, cordycepin, were investigated to characterize their potential effects on adipogenesis and lipolysis. Treatment with CM or cordycepin reduced lipid droplets and increased hormone-sensitive lipase activation in 3T3-L1 cells. In a diabetic obese mouse model, CM and cordycepin lowered serum low-density lipoprotein/very low-density lipoprotein levels and reduced oxidative stress and cell senescence markers. Thus, cordycepin inhibits preadipocyte differentiation and promotes lipolysis, which may serve as a novel obesity treatment. Further studies, including clinical trials, are required to validate the clinical potential of cordycepin.

摘要

肥胖是一个全球性的健康问题，它是由能量失衡导致脂质积累引起的。在本研究中，对北虫草提取物（CM）及其主要成分虫草素进行了研究，以确定它们对脂肪生成和脂肪分解的潜在影响。用CM或虫草素处理可减少3T3-L1细胞中的脂滴，并增加激素敏感性脂肪酶的活性。在糖尿病肥胖小鼠模型中，CM和虫草素可降低血清低密度脂蛋白/极低密度脂蛋白水平，并减少氧化应激和细胞衰老标志物。因此，虫草素可抑制前脂肪细胞分化并促进脂肪分解，这可能成为一种新型的肥胖治疗方法。需要进一步的研究，包括临床试验，来验证虫草素的临床潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93be/11788751/ed79de04e509/FEB4-15-335-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93be/11788751/cf6570bf1b13/FEB4-15-335-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93be/11788751/d477a721f1da/FEB4-15-335-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93be/11788751/d743896ed72e/FEB4-15-335-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93be/11788751/ed79de04e509/FEB4-15-335-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93be/11788751/cf6570bf1b13/FEB4-15-335-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93be/11788751/d477a721f1da/FEB4-15-335-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93be/11788751/d743896ed72e/FEB4-15-335-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93be/11788751/ed79de04e509/FEB4-15-335-g005.jpg

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