Zi Zhi-Feng, Xie Fei, Wang Wen-Jing, Xia Dan-Dan, Wan Dai-Yu, Geng Yan, Dong Hai-Xia, Gao Yu-Hong, Zhou Hao, Ma Ling
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, China.
Department of Clinical Laboratory, The First People's Hospital of Yunnan Province (Affiliated Hospital of Kunming University of Science and Technology), Kunming, China.
Chem Biodivers. 2025 Apr;22(4):e202402744. doi: 10.1002/cbdv.202402744. Epub 2024 Dec 3.
Two previously undescribed chroman-type polyketides, trichrontides A (1) and B (2), along with four known homologous compounds, were isolated from the endophytic fungus Trichoderma sp. YUD24002, which was associated with Aconitum forrestii Stapf. Their structures were confirmed using NMR and HR-ESI-MS techniques. Furthermore, the absolute configurations of the two new compounds were elucidated through TDDFT ECD calculations and Mosher's methods. Notably, compound 1 exhibited significant antifungal activity against Alternaria panax, with a minimum inhibitory concentration (MIC) of 16 µg/mL, while compound 2 demonstrated evident antifungal activity against Epicoccum nigrum, with a MIC of 32 µg/mL.
从与川滇乌头（Aconitum forrestii Stapf）相关的内生真菌木霉属Trichoderma sp. YUD24002中分离出两种之前未描述过的色满型聚酮化合物，即曲霉酮A（1）和B（2），以及四种已知的同系化合物。使用核磁共振（NMR）和高分辨电喷雾电离质谱（HR-ESI-MS）技术确定了它们的结构。此外，通过含时密度泛函理论电子圆二色谱（TDDFT ECD）计算和莫舍尔方法阐明了这两种新化合物的绝对构型。值得注意的是，化合物1对人参链格孢（Alternaria panax）表现出显著的抗真菌活性，最低抑菌浓度（MIC）为16 µg/mL，而化合物2对黑附球菌（Epicoccum nigrum）表现出明显的抗真菌活性, MIC为32 µg/mL。
