Yuko Oguma, Sports Medicine Research Center, Keio University, 4-1-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8521, Japan, Phon: +81-45-566-1090, FAX: +81-45-566-1067, E-mail:
J Frailty Aging. 2024;13(4):413-420. doi: 10.14283/jfa.2024.57.
While physical activity (PA) can reduce physical frailty, the specific intensity and duration of PA required to prevent frailty are yet to be defined.
This study aimed to investigate the relationship between objectively measured PA or sedentary behavior (SB) and physical frailty and to explore the theoretical effect of replacing SB with different intensities of PA on the risk of frailty.
Cross-sectional study.
Community-based assessments.
Independently living adults aged 85-89 years participating in the Kawasaki Aging and Wellbeing Project.
PA was measured using a triaxial accelerometer for a minimum of 10 h per day over a minimum of 3 days. Physical frailty was measured using the revised Japanese version of the Cardiovascular Health Study criteria. Physical frailty was classified as non-frail, pre-frail, and frail. The relationship between PA and frailty was assessed using analysis of covariance. The effect of replacing SB with light-intensity PA (LPA) or moderate-to-vigorous-intensity PA (MVPA) on the risk of frailty was estimated using multinomial logistic regression and an isotemporal substitution model.
The analysis included 1004 participants (503 men and 501 women) of whom 242 were classified as frail. The mean step count, MVPA, and LPA were lower, and SB was higher in the frail group than in the non-frail group. SB replacement with MVPA for 10 min/day was associated with a significantly lower odds of frailty (odds ratio [95% confidence interval]: pre-frail men, 0.86 [0.77, 0.96]; frail men, 0.70 [0.60, 0.83]; pre-frail women, 0.77 [0.66, 0.90], frail women, 0.59 [0.47, 0.75]). SB replacement with LPA was not significantly associated with frailty odds in men or women.
Replacing 10 min of SB with MVPA was associated with lower risk of frailty in adults aged 85-89 years. These findings require confirmation in longitudinal and intervention studies.
体力活动（PA）可以减少身体虚弱，但预防虚弱所需的 PA 具体强度和持续时间仍有待确定。
本研究旨在调查客观测量的 PA 或久坐行为（SB）与身体虚弱之间的关系，并探讨用不同强度的 PA 替代 SB 对虚弱风险的理论影响。
横断面研究。
基于社区的评估。
参加川崎老龄化和健康项目的 85-89 岁独立生活的成年人。
使用三轴加速度计至少每天测量 10 小时，至少连续 3 天。使用修订后的心血管健康研究标准的日本版测量身体虚弱。将身体虚弱分为非虚弱、虚弱前期和虚弱。使用协方差分析评估 PA 与虚弱之间的关系。使用多项逻辑回归和等时替代模型估计用低强度 PA（LPA）或中高强度 PA（MVPA）替代 SB 对虚弱风险的影响。
分析包括 1004 名参与者（503 名男性和 501 名女性），其中 242 名被归类为虚弱。虚弱组的平均步数、MVPA 和 LPA 较低，SB 较高。每天用 MVPA 替代 10 分钟 SB 与虚弱的几率显著降低相关（优势比[95%置信区间]：虚弱前期男性，0.86[0.77, 0.96]；虚弱男性，0.70[0.60, 0.83]；虚弱前期女性，0.77[0.66, 0.90]；虚弱女性，0.59[0.47, 0.75]）。用 LPA 替代 SB 与男性或女性的虚弱几率无关。
每天用 10 分钟 SB 替代 MVPA 与 85-89 岁成年人虚弱风险降低相关。这些发现需要在纵向和干预研究中得到证实。
