Flynn P M, Shenep J L, Stokes D C, Hildner W K, Mackert P W, Snellgrove R L, Rehg J E
Infect Immun. 1986 Apr;52(1):26-30. doi: 10.1128/iai.52.1.26-30.1986.
To determine the effect of methylprednisolone administration on the clearance of bacteremia and the release and clearance of endotoxin during antibiotic therapy of gram-negative bacterial sepsis, Escherichia coli K1 sepsis was induced in paired rabbits. Moxalactam and either methylprednisolone or placebo were administered to infected rabbits 1.5 h after intraperitoneal administration of live bacteria. Serial blood samples were obtained for quantitation of bacteremia and endotoxemia, arterial blood gases, and complete blood count. Arterial blood pressure, heart rate, and core body temperature were also monitored. There were no significant differences between the methylprednisolone-treated and placebo-treated groups in either the levels of bacteremia or endotoxemia or in the physiologic, metabolic, or hematologic parameters that were measured. We conclude that methylprednisolone administration has no acute effect on bacterial clearance or on the kinetics of endotoxin release and clearance during antibiotic therapy of gram-negative bacterial sepsis in this experimental model.
为了确定在革兰氏阴性菌败血症的抗生素治疗期间给予甲基强的松龙对菌血症清除以及内毒素释放和清除的影响，在配对的兔子中诱导大肠杆菌K1败血症。在腹腔注射活细菌1.5小时后，给感染的兔子使用氨曲南和甲基强的松龙或安慰剂。采集系列血样以定量菌血症和内毒素血症、动脉血气和全血细胞计数。还监测动脉血压、心率和核心体温。在菌血症或内毒素血症水平以及所测量的生理、代谢或血液学参数方面，甲基强的松龙治疗组和安慰剂治疗组之间均无显著差异。我们得出结论，在该实验模型中，在革兰氏阴性菌败血症的抗生素治疗期间，给予甲基强的松龙对细菌清除或内毒素释放及清除动力学没有急性影响。
