Heine K J, Shallcross J C, Trachtenberg L S, Galland R B, Polk H C
Am Surg. 1983 Apr;49(4):221-4.
The impact of corticosteroids on host defense processes has been studied frequently because of its obvious clinical significance in many surgical patients. A technique that quantifies intraleukocyte iodination was used to measure polymorphonuclear leukocyte phagocytosis in heat inactivated and nonheat inactivated sera in the presence of two different corticosteroids: hydrocortisone sodium phosphate (HSP) and methylprednisolone sodium succinate (MSS). HSP produced a significant reduction in phagocytosis in the cells of healthy subjects when both heat inactivated autologous and isologous serum samples were used. MSS showed no such effect. Conversely, MSS produced a significant reduction in phagocytosis in the cells of healthy subjects when nonheat inactivated autologous serum was used but not when isologous serum was used. These data generally tend to confirm previous studies suggesting that MSS is less deleterious to some host defense processes than HSP and may be the steroid of choice when infection threatens the recipient.
由于皮质类固醇在许多外科手术患者中具有明显的临床意义，因此对其对宿主防御过程的影响进行了频繁研究。一种量化白细胞内碘化作用的技术被用于在两种不同的皮质类固醇：磷酸氢化可的松钠（HSP）和琥珀酸钠甲泼尼龙（MSS）存在的情况下，测量热灭活和非热灭活血清中的多形核白细胞吞噬作用。当使用热灭活的自体和同种血清样本时，HSP会使健康受试者细胞中的吞噬作用显著降低。MSS没有这种作用。相反，当使用非热灭活的自体血清时，MSS会使健康受试者细胞中的吞噬作用显著降低，但使用同种血清时则不会。这些数据总体上倾向于证实先前的研究，表明MSS对某些宿主防御过程的危害小于HSP，并且在感染威胁接受者时可能是首选的类固醇。
