De La Torre Sergio A, Morcos Marco, Saab Sammy, Shetty Akshay
Department of Medicine, University of California, Los Angeles, CA, USA.
Department of Surgery, Pfleger Liver Institute, UCLA Medical Center, 100 Medical Plaza, Suite 700, Los Angeles, CA, 90095, USA.
Dig Dis Sci. 2025 Jan;70(1):74-84. doi: 10.1007/s10620-024-08705-1. Epub 2024 Nov 22.
Alcohol-associated hepatitis, considered a severe form of alcohol-associated liver disease, carries with it multiple negative health outcomes ranging not only to increased hospitalizations but also increased rates of mortality. While the inpatient management remains critical in optimizing clinical outcomes, a shift in focus to the outpatient management of alcohol-associated hepatitis is warranted as a long-term solution to this emerging health pandemic. Here, we review the clinical presentation, diagnosis, and current prognostication scoring systems for alcohol-associated hepatitis. We then offer a multimodal approach to the continued management of alcohol-associated hepatitis in the outpatient setting encompassing not only nutritional optimization, alcohol use disorder treatment, and the medical management of chronic liver disease, but also briefly review the current trend of the use of liver transplantation.
酒精性肝炎被认为是酒精性肝病的一种严重形式，会带来多种负面健康后果，不仅会增加住院率，还会提高死亡率。虽然住院治疗对于优化临床结果仍然至关重要，但将重点转向酒精性肝炎的门诊管理作为应对这一新兴健康大流行的长期解决方案是有必要的。在此，我们回顾了酒精性肝炎的临床表现、诊断和当前的预后评分系统。然后，我们提供了一种多模式方法，用于在门诊环境中持续管理酒精性肝炎，不仅包括营养优化、酒精使用障碍治疗和慢性肝病的药物管理，还简要回顾了目前肝移植使用的趋势。
