Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo (USP), Pirassununga, São Paulo, Brazil.
Department of Veterinary Medicine and Surgery, Faculty of Agricultural and Veterinary Sciences, UNESP-São Paulo State University, Jaboticabal, São Paulo, Brazil.
PLoS One. 2024 Nov 22;19(11):e0313563. doi: 10.1371/journal.pone.0313563. eCollection 2024.
Submitting late-term pregnant mares to anesthesia for non-obstetric surgery raises concerns about the survival of the mother and fetus. This study aimed to evaluate and describe transient maternal and fetal hemodynamic changes during general inhalation anesthesia in mares during the last month of gestation. Nine adult mares in the last month of gestation were subjected to general inhalation anesthesia and dorsal recumbency for 90 minutes. Trans-anesthetic vital parameters, arterial hemogasometry, cardiac output, pulmonary arterial pressure, central venous pressure, and fetal heart rates were assessed at defined intervals. During various timespans of the anesthetic procedure, the mares demonstrated an increase in heart rate, mean arterial pressure, and diastolic pressure as well as a decrease in temperature. Additionally, arterial hemogasometry indicated respiratory acidosis. No changes in cardiac output were observed; however, there was a reduction in pulmonary arterial and central venous pressures and stroke volume. Fetal heart rate was significantly decreased. General inhalation anesthesia in late term pregnancy in mares in a recumbent position implies in significant hemodynamic and metabolic changes. Up to 90 minutes those changes does not seem to affect negatively the maternal-fetus prognosis.
将晚期妊娠母马麻醉进行非产科手术会引起对母马和胎儿生存的担忧。本研究旨在评估和描述妊娠最后一个月母马全身吸入麻醉期间的短暂母体和胎儿血液动力学变化。将 9 匹妊娠最后一个月的成年母马置于全身吸入麻醉和背卧位，持续 90 分钟。在规定的时间间隔内评估麻醉过程中的跨麻醉生命参数、动脉血气、心输出量、肺动脉压、中心静脉压和胎儿心率。在麻醉过程的不同时间段，母马的心率、平均动脉压和舒张压增加，体温降低。此外，动脉血气表明存在呼吸性酸中毒。心输出量没有变化；然而，肺动脉压、中心静脉压和每搏量降低。胎儿心率显著降低。妊娠晚期仰卧位母马全身吸入麻醉会导致明显的血液动力学和代谢变化。在长达 90 分钟的时间内，这些变化似乎不会对母婴预后产生负面影响。
