中国改良心智饮食与中国中老年人群认知功能的关联：来自中国广场舞队列研究的结果。

The association between Chinese adapted MIND diet and cognitive function in Chinese middle-aged and older adults: results from the Chinese Square Dance Cohort.

机构信息

Academy of Nutrition and Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology; Hongshan Central Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, 430065, China.

Department of Clinical Nutrition, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.

出版信息

Eur J Nutr. 2024 Nov 23;64(1):22. doi: 10.1007/s00394-024-03522-8.

DOI:10.1007/s00394-024-03522-8

PMID:39579171

Abstract

PURPOSE

This study aimed to assess the relationship between Chinese adapted MIND diet and cognitive functioning and performance in different cognitive domains across a cross-section of Chinese middle-aged and older adults.

METHODS

This cross-sectional study used baseline data from the Lifestyle and Healthy Ageing in Chinese Square Dancers study. Chinese adapted MIND diet scores were calculated from a detailed retrospective semi-quantitative food frequency questionnaire assessment. By averaging the z-scores of Auditory Verbal Learning Test (AVLT), Verbal Fluency Test (VFT), Digital Symbol Substitution Test (DSST), and Trail Making Test-B (TMT-B), a comprehensive z-score is obtained to represent global cognition. Mild cognitive impairment (MCI) was diagnosed based on Petersen's criteria. Multiple linear regression models were used to analyze the relationship between Chinese adapted MIND diet scores and z-scores of cognitive functions, and multiple logistic regression models were used to assess the association between diet scores and MCI.

RESULTS

In this study, a total of 4335 participants were included, whose mean age was 63.61 years (SD = 5.15), 85.07% were female, and 13.33% (578/4335) of them had MCI. In the fully adjusted model, the group with the highest diet scores had the best cognitive function compared to the group with the lowest diet scores (P < 0.05), including global cognitive function (β = 0.10, 95% CI: 0.05, 0.15), AVLT (β = 0.12, 95% CI: 0.03, 0.20), VFT (β = 0.12, 95% CI: 0.03, 0.20), DSST (β = 0.07, 95% CI: 0.00, 0.14), and TMT-B (β =-0.10, 95% CI: -0.18, -0.01). In addition, compared to the lowest group, the highest diet scores group were associated with lower odd ratio of MCI (OR = 0.69, 95% CI: 0.51, 0.93).

CONCLUSIONS

Our findings support that higher adherence to Chinese adapted MIND diet is associated with better cognitive function and lower prevalence odds ratio for MCI in a Chinese middle-aged and older population.

摘要

目的

本研究旨在评估中国改良 MIND 饮食与认知功能和不同认知领域表现之间的关系，研究对象为中国中老年人群。

方法

本横断面研究使用了来自“中国广场舞人群生活方式与健康老龄化研究”的基线数据。中国改良 MIND 饮食评分通过详细的回顾性半定量食物频率问卷评估得出。通过对听觉词语学习测试（AVLT）、词语流畅性测试（VFT）、数字符号替代测试（DSST）和连线测试 B（TMT-B）的 z 分数进行平均，得到一个综合 z 分数来代表整体认知功能。基于 Petersen 标准，诊断出轻度认知障碍（MCI）。采用多元线性回归模型分析中国改良 MIND 饮食评分与认知功能 z 分数之间的关系，采用多元逻辑回归模型评估饮食评分与 MCI 的关联。

结果

本研究共纳入 4335 名参与者，平均年龄为 63.61 岁（标准差=5.15），85.07%为女性，13.33%（578/4335）患有 MCI。在完全调整模型中，与最低饮食评分组相比，最高饮食评分组的认知功能更好（P<0.05），包括整体认知功能（β=0.10，95%置信区间：0.05，0.15）、AVLT（β=0.12，95%置信区间：0.03，0.20）、VFT（β=0.12，95%置信区间：0.03，0.20）、DSST（β=0.07，95%置信区间：0.00，0.14）和 TMT-B（β=-0.10，95%置信区间：-0.18，-0.01）。此外，与最低评分组相比，最高评分组 MCI 的比值比（OR）较低（OR=0.69，95%置信区间：0.51，0.93）。