Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
University of Bordeaux, Bordeaux, France.
Alzheimers Dement. 2023 Aug;19(8):3644-3653. doi: 10.1002/alz.12982. Epub 2023 Feb 28.
Cognitive resilience (CR) can be defined as the continuum of better through worse than expected cognition, given the degree of neuropathology. The relation of healthy diet patterns to CR remains to be elucidated.
Using longitudinal cognitive data and post mortem neuropathology from 578 deceased older adults, we examined associations between the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet at baseline and two standardized CR measures reflecting higher cognitive levels over time (CR ), and slower decline (CR ), than expected given neuropathology.
Compared to individuals in the lowest tertile of MIND score, those in the top tertile had higher CR (mean difference [MD] = 0.34; 95% confidence interval [CI] = 0.14, 0.55) and CR (MD = 0.27; 95% CI = 0.05, 0.48), after multivariable adjustment. Overall MIND score was more strongly related to CR than the individual food components.
The MIND diet is associated with both higher cognition and slower rates of cognitive decline, after controlling for neuropathology, indicating the MIND diet may be important to cognitive resilience.
认知弹性（CR）可定义为在给定神经病理学程度的情况下，认知表现优于或劣于预期的连续体。健康饮食模式与 CR 的关系仍有待阐明。
我们使用 578 名已故老年人的纵向认知数据和死后神经病理学资料，研究了基线时地中海-得舒饮食干预对神经退行性疾病延迟（MIND）饮食与两种反映随着时间推移认知水平更高（CR ）和下降更慢（CR ）的标准化 CR 测量值之间的关系，这些测量值反映了与神经病理学相比预期更高的认知水平。
与 MIND 评分最低三分位的个体相比，最高三分位的个体具有更高的 CR （平均差异 [MD] = 0.34；95%置信区间 [CI] = 0.14，0.55）和 CR （MD = 0.27；95%CI = 0.05，0.48），经过多变量调整后。总体而言，MIND 饮食与 CR 的相关性强于单个食物成分。
在控制神经病理学后，MIND 饮食与更高的认知能力和更慢的认知衰退速度相关，这表明 MIND 饮食可能对认知弹性很重要。
