Salomoni Paolo
Nuclear Function Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Mol Oncol. 2024 Dec;18(12):2817-2821. doi: 10.1002/1878-0261.13769. Epub 2024 Nov 25.
Brain cancer is one of the most devastating neoplasms affecting both children and adults. Its dismal prognosis has for long-time discouraged research in this area. However, in the last 10-15 years remarkable progress has been made in our understanding of brain cancer biology, thus showing promise for the identification of new ways to treat these tumors towards the improvement of patients' survival and quality of life. This Thematic Issue on Brain cancers offers a much needed and timely critical overview of the fundamental discoveries in this area of research and which of those are more promising for effective translation into the clinic. Critically, many Reviews from this Issue also provide discussion points on why the field has not progressed as much as it had hoped to. It is important to emphasize however that we are living in exciting times with regards to our ability to translate fundamental findings into the clinic thanks to the enormous technological advances facilitating the study of cancer genomes and the development of new drugs or repurposing existing agents.
脑癌是影响儿童和成人的最具毁灭性的肿瘤之一。其预后不佳长期以来阻碍了该领域的研究。然而，在过去10至15年里，我们对脑癌生物学的理解取得了显著进展，这为寻找治疗这些肿瘤的新方法以提高患者生存率和生活质量带来了希望。本期关于脑癌的专题提供了对该研究领域基础发现的急需且及时的批判性综述，以及哪些发现更有希望有效转化为临床应用。至关重要的是，本期的许多综述还讨论了为何该领域没有像预期那样取得很大进展。然而，必须强调的是，鉴于癌症基因组研究、新药开发或现有药物重新利用等方面的巨大技术进步极大地推动了基础研究成果向临床应用的转化，我们正处于一个令人兴奋的时代。
