Famili K, Gholami M, Shahri A
Mashhad dental school Mashhad university of medical sciences university campus P.O. Box: 9178613111, Mashhad, Iran
Med Oral Patol Oral Cir Bucal. 2025 Jan 1;30(1):e41-e48. doi: 10.4317/medoral.26820.
To evaluate the efficacy of a novel topical dressing (composed of triamcinolone, ground Dianthus caryophyllus, eugenol, honey, and Iris germanica) for alveolar osteitis (dry socket) against Alvogyl® (composed of eugenol, butamben, and iodoform).
In a randomized parallel-armed clinical trial at Mashhad Dental School's Department of Oral and Maxillofacial Surgery, 36 patients with alveolar osteitis were randomly allocated into two groups according to the inclusion criteria (n=18), using sealed envelopes: one receiving a novel topical dressing and the other receiving Alvogyl®. Post-treatment pain was assessed using a visual analog scale immediately after the procedure and at 30 and 60 minutes, 24, 48, 72, and 96 hours, and one week later, as well as the frequency of dressing applications and analgesic usage. Data analysis was performed using SPSS version 26.
Analyses were completed on all 36 participants without dropouts. No significant age or gender differences were found between the groups at baseline (p=0.370 and p=0.502, respectively). The novel dressing group experienced significantly lower pain scores at 30 and 60 minutes post-treatment (p<0.001), but higher scores at 24 (p=0.029), 48 (p=0.001), and 72 (p=0.017) hours, and similar pain scores immediately after the procedure and at 96 hours and 1 week (p>0.05), compared to the Alvogyl® group. The mean number of analgesics taken (p=0.097) and the mean frequency of dressing application (p=0.839) were not significantly different between the two groups.
The novel topical dressing demonstrated efficacy comparable to Alvogyl®, with the added benefits of cost-effectiveness and the absence of side effects, suggesting its potential as an alternative treatment for dry socket.
评估一种新型局部敷料（由曲安奈德、康乃馨粉、丁香酚、蜂蜜和鸢尾组成）治疗干槽症的疗效，并与Alvogyl®（由丁香酚、布坦本和碘仿组成）进行对比。
在马什哈德牙科学院口腔颌面外科进行的一项随机平行分组临床试验中，36例干槽症患者根据纳入标准随机分为两组（n = 18），采用密封信封法：一组接受新型局部敷料，另一组接受Alvogyl®。术后立即、30分钟、60分钟、24小时、48小时、72小时、96小时及1周后，使用视觉模拟量表评估治疗后疼痛情况，同时记录敷料使用频率和镇痛药物使用情况。使用SPSS 26版软件进行数据分析。
对所有36名参与者进行了分析，无脱落病例。两组在基线时年龄和性别无显著差异（分别为p = 0.370和p = 0.502）。与Alvogyl®组相比，新型敷料组在治疗后30分钟和60分钟时疼痛评分显著更低（p < 0.001），但在24小时（p = 0.029）、48小时（p = 0.001）和72小时（p = 0.017）时疼痛评分更高，在术后立即、96小时和1周时疼痛评分相似（p > 0.05）。两组的平均镇痛药物服用量（p = 0.097）和平均敷料使用频率（p = 0.839）无显著差异。
新型局部敷料显示出与Alvogyl®相当的疗效，且具有成本效益和无副作用的额外优势，表明其作为干槽症替代治疗方法的潜力。
