Wang Xiaoxi, Zhu Keqing, Wu Wei, Zhou Dan, Lu Hui, Du Juan, Cai Li, Yan Xiaoxin, Li Wensheng, Qian Xiaojing, Wang Xue, Ma Chao, Hu Yuting, Tian Chen, Sun Bing, Fang Zheng, Wu Juanli, Jiang Peiran, Liu Jianxin, Liu Cuiyun, Fan Jiayao, Cui Huixian, Shen Yi, Duan Shumin, Bao Aimin, Yang Ying, Qiu Wenying, Zhang Jing
Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
National Health and Disease Human Brain Tissue Resource Center, School of Medicine, Zhejiang University, Hangzhou, China.
Alzheimers Dement. 2025 Jan;21(1):e14369. doi: 10.1002/alz.14369. Epub 2024 Nov 25.
Despite extensive studies on mixed neuropathologies, data from China are limited. This study aims to fill this gap by analyzing brain samples from Chinese brain banks.
A total of 1142 brains from six Chinese brain banks were examined using standardized methods. Independent pathologists conducted evaluations with stringent quality control. Prevalence and correlations of neurological disorders were analyzed.
Significant proportions of brains displayed primary age-related tauopathy (PART, 35%), limbic-predominant age-related TDP-43 encephalopathy (LATE, 46%), and aging-related tau astrogliopathy (ARTAG, 12%). Alzheimer's disease neuropathological change (ADNC, 48%), Lewy body disease (LBD, 13%), and cerebrovascular disease (CVD, 63%) were also prevalent, often co-occurring with regional variations. CVD emerged as the potential most early contributor to neuropathological changes.
This analysis highlights the prevalence of PART, LATE, ARTAG, ADNC, LBD, and CVD, with regional differences. The findings suggest CVD may be the earliest contributing factor, potentially preceding other neuropathologies. Highlights The prevalence of primary age-related tauopathy (PART), limbic-predominant age-related TDP-43 encephalopathy (LATE), aging-related tau astrogliopathy (ARTAG), Alzheimer's disease neuropathologic change, Lewy body disease, and cerebrovascular disease (CVD) in China, increasing with age, is comparable to other countries. Significant regional differences in the prevalences of diseases are noted. CVD develops prior to any other disorders, including PART, LATE, and ARTAG.
尽管对混合神经病理学进行了广泛研究，但来自中国的数据有限。本研究旨在通过分析中国脑库的脑样本填补这一空白。
使用标准化方法检查了来自六个中国脑库的总共1142个大脑。独立病理学家进行评估并实施严格的质量控制。分析了神经系统疾病的患病率及相关性。
相当比例的大脑表现出原发性年龄相关性tau病（PART，35%）、边缘叶为主的年龄相关性TDP-43脑病（LATE，46%）和衰老相关性tau星形胶质细胞病（ARTAG，12%）。阿尔茨海默病神经病理改变（ADNC，48%）、路易体病（LBD，13%）和脑血管疾病（CVD，63%）也很常见，且常伴有区域差异。CVD成为神经病理改变潜在的最早促成因素。
该分析突出了PART、LATE、ARTAG、ADNC、LBD和CVD的患病率及区域差异。研究结果表明CVD可能是最早的促成因素，可能先于其他神经病理学改变出现。要点：中国原发性年龄相关性tau病（PART）、边缘叶为主的年龄相关性TDP-43脑病（LATE）、衰老相关性tau星形胶质细胞病（ARTAG）、阿尔茨海默病神经病理改变、路易体病和脑血管疾病（CVD）的患病率随年龄增长，与其他国家相当。注意到疾病患病率存在显著区域差异。CVD在包括PART、LATE和ARTAG在内的任何其他疾病之前出现。
Zotero 插件
