中国一个尸检确诊队列中脑淀粉样血管病的患病率及其与阿尔茨海默病和认知的相关性
Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy-confirmed cohort from China.
作者信息
Yin Xiang-Sha, Sun Jianru, Wang Xue, Wu Wei, Chen Zhen, Zhang Di, Xu Yuanyuan, Chen Yongmei, Qiu Wenying, Qian Xiaojing, Ni Jun, Ma Chao
机构信息
Department of Human Anatomy Histology and Embryology Institute of Basic Medical Sciences Neuroscience Center Joint Laboratory of Anesthesia and Pain Chinese Academy of Medical Sciences Peking Union Medical College Beijing China.
National Human Brain Bank for Development and Function Beijing China.
出版信息
Alzheimers Dement (Amst). 2025 Apr 6;17(2):e70100. doi: 10.1002/dad2.70100. eCollection 2025 Apr-Jun.
BACKGROUND
We aimed to investigate the prevalence of cerebral amyloid angiopathy (CAA) and its correlations with Alzheimer's disease (AD) and cognitive impairment in an autopsy-confirmed cohort donated to a human brain bank in Beijing, China.
METHODS
A total of 483 subjects were neuropathologically evaluated based on standardized protocols. Descriptive statistics and ordinal logistic regression models were used to estimate the correlation between CAA, AD, apolipoprotein E () genotyping, and cognitive function proximal to death.
RESULTS
Neuropathological assessment revealed that 53 of 483 subjects (11%) had CAA without AD, 78 of 483 (16%) had AD without CAA, 98 of 483 (20%) had both CAA and AD, and 254 of 483 (53%) had neither condition. A significant correlation was confirmed between CAA severity and AD. Subjects with both CAA and AD exhibited aggravated cognitive impairment.
DISCUSSION
Our results indicate a substantial prevalence of CAA that is frequently comorbid with AD and may exacerbate cognitive decline in the elderly population in China.
HIGHLIGHTS
First reporting of cerebral amyloid angiopathy (CAA) based on an autopsy-confirmed cohort from China.The prevalence of CAA was high in the elderly Chinese sample.Age and apolipoprotein E () ε4 allele were related to the prevalence of CAA.CAA and Alzheimer's disease (AD) were frequently co-occurred and significantly associated.Subjects with both CAA and AD exhibited aggravated cognitive impairment.
背景
我们旨在调查在中国北京一个捐赠给人脑库的经尸检确诊的队列中脑淀粉样血管病（CAA）的患病率及其与阿尔茨海默病（AD）和认知障碍的相关性。
方法
根据标准化方案对总共483名受试者进行神经病理学评估。使用描述性统计和有序逻辑回归模型来估计CAA、AD、载脂蛋白E（）基因分型与死亡前认知功能之间的相关性。
结果
神经病理学评估显示，483名受试者中有53名（11%）患有无AD的CAA，483名中有78名（16%）患有无CAA的AD，483名中有98名（20%）同时患有CAA和AD，483名中有254名（53%）两者均无。CAA严重程度与AD之间存在显著相关性。同时患有CAA和AD的受试者表现出更严重的认知障碍。
讨论
我们的结果表明CAA的患病率较高，且常与AD合并存在，并可能加剧中国老年人群的认知衰退。
要点
首次基于来自中国的经尸检确诊的队列报告脑淀粉样血管病（CAA）。中国老年样本中CAA的患病率较高。年龄和载脂蛋白E（）ε4等位基因与CAA的患病率相关。CAA和阿尔茨海默病（AD）经常同时出现且显著相关。同时患有CAA和AD的受试者表现出更严重的认知障碍。
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