Musa Sultan Malik, Hussein Abdullah Talib, Abbas Abdullah Mohammed, Al-Darkazali Waleed, Sattar Harbi Nazar
College of Science, Mustansiriyah University, Palestine Street, Baghdad, Iraq.
Rep Biochem Mol Biol. 2024 Apr;13(1):23-30. doi: 10.61186/rbmb.13.1.23.
Prostate cancer is a classic public health problem in males and has broadly different levels of mortality and morbidity. As an endocrine gland, adipose tissue synthesizes and secretes a variety of bioactive peptides, such as irisin and omentin-1. Adipokines and oxidative stress potentially contribute to the proliferation of prostatic carcinoma cells. The relationship between irisin, omentin-1, and oxidative stress has not been widely investigated in prostate cancer. Therefore, the present research assessed whether there is a significant correlation between irisin and omentin-1 levels and oxidative status in prostate cancer individuals.
The present research recruited 40 individuals diagnosed with prostate cancer and 40 healthy individuals for comparative purposes. All individuals underwent demographics, biochemicals, and serum adipokines (irisin and omentin-1) data analysis.
The means of total prostate-specific antigen (43.3±20.5 vs. 2.5±1.2) and free prostate-specific antigen (2.1±1.4 vs. 0.08±0.02) were highly significant increases in the prostate cancer patients than in the healthy individuals. Furthermore, the means of omentin-1 (31.6±12.8 vs. 23.5±14.1) and total oxidant stress (22.4±10.6 vs. 9.1±3.6) were highly significant increases in patients with prostate cancer than in healthy individuals. In contrast, the means of irisin (343.5±240.2 vs. 716.4±142.3) and total antioxidant capacity (2.2±1.2 vs. 3.3±1.3) were highly significant decreases in patients with prostate cancer than in healthy individuals. No significant relationship was demonstrated between all parameters in the two groups under study.
The study findings indicate that irisin and omentin-1 could serve as biomarkers for predicting prostate cancer.
前列腺癌是男性典型的公共卫生问题，其死亡率和发病率差异很大。作为一种内分泌腺，脂肪组织合成并分泌多种生物活性肽，如鸢尾素和网膜素-1。脂肪因子和氧化应激可能促进前列腺癌细胞的增殖。鸢尾素、网膜素-1与氧化应激之间的关系在前列腺癌中尚未得到广泛研究。因此，本研究评估了前列腺癌患者中鸢尾素和网膜素-1水平与氧化状态之间是否存在显著相关性。
本研究招募了40名被诊断为前列腺癌的个体和40名健康个体进行比较。所有个体均接受了人口统计学、生化指标和血清脂肪因子（鸢尾素和网膜素-1）数据分析。
前列腺癌患者的总前列腺特异性抗原（43.3±20.5 vs. 2.5±1.2）和游离前列腺特异性抗原（2.1±1.4 vs. 0.08±0.02）均值较健康个体显著升高。此外，前列腺癌患者的网膜素-1（31.6±12.8 vs. 23.5±14.1）和总氧化应激（22.4±10.6 vs. 9.1±3.6）均值较健康个体显著升高。相反，前列腺癌患者的鸢尾素（343.5±240.2 vs. 716.4±142.3）和总抗氧化能力（2.2±1.2 vs. 3.3±1.3）均值较健康个体显著降低。在研究的两组中，所有参数之间均未显示出显著关系。
研究结果表明，鸢尾素和网膜素-1可作为预测前列腺癌的生物标志物。
