Tang Xiaoqiong, Tay Alfred, Benghezal Mohammed, Marshall Barry J, Tang Hong, Li Hong
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Laboratory of Infectious and Liver Diseases, Institution of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China.
FEMS Microbiol Rev. 2025 Jan 14;49. doi: 10.1093/femsre/fuaf034.
Helicobacter pylori is a widespread pathogen responsible for chronic gastritis, peptic ulcers, and an elevated risk of gastric cancer. Lipopolysaccharide (LPS), localized exclusively in the outer leaflet of the outer membrane, is essential for maintaining bacterial integrity. Recent advances have deepened our understanding of H. pylori LPS structure, particularly lipid A modifications and the redefinition of the core oligosaccharide and O-antigen regions. The complete set of enzymes involved in LPS biosynthesis has been identified in the reference strain G27, and comparative genomics has revealed a notable regional difference (the absence of the heptan domain in East Asian strains). Here, we summarize recent insights into the structure and function of H. pylori LPS, emphasizing its role in bacterial persistence and its promise as a target for LPS-based glycoconjugate vaccine development.
幽门螺杆菌是一种广泛传播的病原体，可导致慢性胃炎、消化性溃疡，并增加患胃癌的风险。脂多糖（LPS）仅位于外膜的外层小叶中，对维持细菌的完整性至关重要。最近的进展加深了我们对幽门螺杆菌LPS结构的理解，特别是脂质A修饰以及核心寡糖和O抗原区域的重新定义。在参考菌株G27中已鉴定出参与LPS生物合成的全套酶，比较基因组学揭示了一个显著的区域差异（东亚菌株中不存在庚糖结构域）。在这里，我们总结了对幽门螺杆菌LPS结构和功能的最新见解，强调其在细菌持久性中的作用以及作为基于LPS的糖缀合物疫苗开发靶点的前景。
