Vishwakarma Subrat, Tiwari Om Shanker, Shukla Ruchi, Gazit Ehud, Makam Pandeeswar
Department of Chemistry, Indian Institute of Technology (BHU), Varanasi, UP, 221005, India.
The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
Chem Soc Rev. 2025 Jan 2;54(1):465-483. doi: 10.1039/d4cs00996g.
In the evolving landscape of biomolecular supramolecular chemistry, recent studies on phenylalanine (Phe) have revealed important insights into the versatile nature of this essential aromatic amino acid. Phe can spontaneously self-assemble into fibrils with amyloid-like properties linked to the neurological disorder phenylketonuria (PKU). Apart from its pathological implications, Phe also displays complex phase behavior and can undergo structural changes in response to external stimuli. Its ability to co-assemble with other amino acids opens up new possibilities for studying biomolecular interactions. Furthermore, Phe's coordination with metal ions has led to the development of enzyme-mimicking catalytic systems for applications in organic chemistry, environmental monitoring, and healthcare. Research on L and D enantiomers of Phe, particularly on bio-MOFs, has highlighted their potential in advanced technologies, including bioelectronic devices. This review provides a comprehensive overview of the advancements in Phe-based supramolecular assemblies, emphasizing their interdisciplinary relevance. The Phe assemblies show great potential for future therapeutic and functional biomaterial developments, from disease treatments to innovations in bionanozymes and bioelectronics. This review presents a compelling case for the ongoing exploration of Phe's biomolecular supramolecular chemistry as a fundamental framework for developing sustainable and efficient methodologies across various scientific disciplines.
在生物分子超分子化学不断发展的领域中，最近关于苯丙氨酸（Phe）的研究揭示了这种必需芳香族氨基酸的多功能性质的重要见解。Phe可以自发地自组装成具有与神经疾病苯丙酮尿症（PKU）相关的淀粉样蛋白样性质的纤维。除了其病理意义外，Phe还表现出复杂的相行为，并且可以响应外部刺激而发生结构变化。它与其他氨基酸共组装的能力为研究生物分子相互作用开辟了新的可能性。此外，Phe与金属离子的配位导致了用于有机化学、环境监测和医疗保健的模拟酶催化系统的开发。对Phe的L和D对映体的研究，特别是对生物金属有机框架（bio-MOFs）的研究，突出了它们在包括生物电子器件在内的先进技术中的潜力。本综述全面概述了基于Phe的超分子组装体的进展，强调了它们的跨学科相关性。Phe组装体在未来治疗和功能性生物材料的开发方面显示出巨大潜力，从疾病治疗到生物纳米酶和生物电子学的创新。本综述为持续探索Phe的生物分子超分子化学作为跨各种科学学科开发可持续和高效方法的基本框架提供了令人信服的案例。
