骨髓细胞与脉冲微波对实验大鼠热损伤皮肤的联合作用

Combined Effects of Bone Marrow Cells and Pulsed Microwaves on Thermally Damaged Skin of Laboratory Rats.

作者信息

Samoylova A V, Gostyukhina A A, Bolshakov M A, Yartsev V V, Evseeva S S, Doroshenko O S, Mochalova V M, Zaitsev K V, Kutenkov O P, Rostov V V, Dambaev G Ts

机构信息

Institute of High Current Electronics, Siberian Branch of the Russian Academy of Sciences, Tomsk, Russia.

National Research Tomsk State University, Tomsk, Russia.

出版信息

Bull Exp Biol Med. 2024 Nov;178(1):91-95. doi: 10.1007/s10517-024-06288-5. Epub 2024 Nov 25.

DOI:10.1007/s10517-024-06288-5

PMID:39585592

Abstract

We studied the effect of bone marrow cells (BMC) and nanosecond repetitively pulsed microwaves (RPMs, 10 GHz, pulse duration 100 nsec, pulse repetition rate 8 Hz, peak power flux density (pPFD) 140 W/cm) on the regeneration of thermally damaged skin in rats. The combined use of BMC and RPMs accelerates separation of an eschar with its complete rejection on day 14 of the experiment. Histological analysis demonstrated a statistically significant increase in the relative area of the granulation tissue and thickness of newly formed epidermis in the group with combined exposure. Combined therapy ensured completion of wound epithelialization in 100% of rats by day 30 of the study.

摘要

我们研究了骨髓细胞（BMC）和纳秒重复脉冲微波（RPMs，10 GHz，脉冲持续时间100纳秒，脉冲重复频率8 Hz，峰值功率通量密度（pPFD）140 W/cm²）对大鼠热损伤皮肤再生的影响。BMC与RPMs联合使用可加速焦痂分离，并在实验第14天实现焦痂完全脱落。组织学分析表明，联合暴露组的肉芽组织相对面积和新形成表皮厚度有统计学意义的增加。联合治疗确保在研究第30天时100%的大鼠伤口上皮化完成。