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Insulin-inspired peptides may open new pathways to treat Alzheimer's disease.

作者信息

Kristensen Mie

机构信息

Central Nervous System Drug Delivery and Barrier Modelling, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2100, Denmark.

出版信息

Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2419741121. doi: 10.1073/pnas.2419741121. Epub 2024 Nov 25.

DOI:10.1073/pnas.2419741121
PMID:39585998
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11626187/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbd6/11626187/27f2810049c4/pnas.2419741121fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbd6/11626187/27f2810049c4/pnas.2419741121fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbd6/11626187/27f2810049c4/pnas.2419741121fig01.jpg

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本文引用的文献

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Insulin-inspired hippocampal neuron-targeting technology for protein drug delivery.胰岛素启发的海马神经元靶向技术用于蛋白药物递送。
Proc Natl Acad Sci U S A. 2024 Oct 8;121(41):e2407936121. doi: 10.1073/pnas.2407936121. Epub 2024 Sep 30.
2
2024 Alzheimer's disease facts and figures.2024 年阿尔茨海默病事实和数据。
Alzheimers Dement. 2024 May;20(5):3708-3821. doi: 10.1002/alz.13809. Epub 2024 Apr 30.
3
Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans.
将 Brainshuttle™淀粉样蛋白-β 抗体融合物 trontinemab 递送至非人灵长类动物脑内和预测在人体中的有效剂量方案。
MAbs. 2023 Jan-Dec;15(1):2261509. doi: 10.1080/19420862.2023.2261509. Epub 2023 Oct 12.
4
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.一种具有血脑屏障转运载体的 TREM2 激活抗体增强了阿尔茨海默病模型中小胶质细胞的代谢。
Nat Neurosci. 2023 Mar;26(3):416-429. doi: 10.1038/s41593-022-01240-0. Epub 2023 Jan 12.
5
Lecanemab in Early Alzheimer's Disease.早期阿尔茨海默病中的lecanemab
N Engl J Med. 2023 Jan 5;388(1):9-21. doi: 10.1056/NEJMoa2212948. Epub 2022 Nov 29.
6
Investigation of the Transport Pathways Associated with Enhanced Brain Delivery of Peptide Drugs by Intranasal Coadministration with Penetratin.通过与穿膜肽鼻腔共同给药来研究与肽类药物增强脑递送相关的转运途径。
Pharmaceutics. 2021 Oct 20;13(11):1745. doi: 10.3390/pharmaceutics13111745.
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Alzheimer disease.阿尔茨海默病。
Nat Rev Dis Primers. 2021 May 13;7(1):33. doi: 10.1038/s41572-021-00269-y.
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Strategies for delivering therapeutics across the blood-brain barrier.穿越血脑屏障递药的策略。
Nat Rev Drug Discov. 2021 May;20(5):362-383. doi: 10.1038/s41573-021-00139-y. Epub 2021 Mar 1.
9
Drug Delivery Strategies to Overcome the Blood-Brain Barrier (BBB).克服血脑屏障(BBB)的药物递送策略。
Handb Exp Pharmacol. 2022;273:151-183. doi: 10.1007/164_2020_403.
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