Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Science, Kerman, Iran.
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
J Mol Neurosci. 2020 Jun;70(6):819-834. doi: 10.1007/s12031-020-01478-y. Epub 2020 Feb 5.
Alzheimer's disease is associated with biochemical and histopathological changes characterized by molecular abnormalities. Due to the lack of effective treatments for Alzheimer's disease, many attempts have been made to find potential therapies to reduce or even return neuronal loss after disease initiation. Alzheimer's disease is also touted as type III diabetes, showing an association with insulin signaling. The large distribution of the insulin receptor on the cell surface and its regulatory role in the central nervous system suggests that the pathogenesis of Alzheimer's disease could be ascribed to insulin signaling. The interference of opioids, such as morphine with insulin signaling pathways, is thought to occur via direct crosstalk between the signaling pathways of the insulin receptor and the mu-opioid receptor. In this review article, we discuss the possible crosstalk between the mu-opioid receptor and insulin signaling pathways. The association of these two signaling pathways with Alzheimer's disease is also debated.
阿尔茨海默病与生化和组织病理学变化有关，其特征是分子异常。由于缺乏有效的阿尔茨海默病治疗方法，许多人试图寻找潜在的治疗方法，以减少甚至逆转疾病发生后的神经元损失。阿尔茨海默病也被称为 III 型糖尿病，与胰岛素信号有关。胰岛素受体在细胞表面的广泛分布及其在中枢神经系统中的调节作用表明，阿尔茨海默病的发病机制可能归因于胰岛素信号。阿片类药物（如吗啡）对胰岛素信号通路的干扰被认为是通过胰岛素受体和μ-阿片受体信号通路的直接串扰发生的。在这篇综述文章中，我们讨论了μ-阿片受体和胰岛素信号通路之间可能存在的串扰。这两种信号通路与阿尔茨海默病的关联也存在争议。
