转运RNA甲基化驱动出生后早期心肌细胞成熟。
tRNA methylation drives early postnatal cardiomyocyte maturation.
作者信息
Ruiz-Lozano Pilar, Mercola Mark
机构信息
Regencor, Inc., San Carlos, CA, USA.
National Heart Lung Institute, Imperial College London, London, UK.
出版信息
Nat Cardiovasc Res. 2024 Dec;3(12):1375-1376. doi: 10.1038/s44161-024-00572-3.
Abstract
Postnatal cardiomyocyte maturation is critical for the heart to sustain pump activity through adulthood. The methyltransferase METTL1 drives cardiomyocyte maturation during the first week of postnatal life in the mouse by enhancing ketogenesis and fatty acid oxidation.
摘要
产后心肌细胞成熟对于心脏在成年期维持泵血活动至关重要。甲基转移酶METTL1通过增强生酮作用和脂肪酸氧化，在小鼠出生后的第一周驱动心肌细胞成熟。
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本文引用的文献
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