心脏成熟
Cardiac maturation.
作者信息
Sakamoto Tomoya, Kelly Daniel P
机构信息
Cardiovascular Institute, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Cardiovascular Institute, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
J Mol Cell Cardiol. 2024 Feb;187:38-50. doi: 10.1016/j.yjmcc.2023.12.008. Epub 2023 Dec 30.
Abstract
The heart undergoes a dynamic maturation process following birth, in response to a wide range of stimuli, including both physiological and pathological cues. This process entails substantial re-programming of mitochondrial energy metabolism coincident with the emergence of specialized structural and contractile machinery to meet the demands of the adult heart. Many components of this program revert to a more "fetal" format during development of pathological cardiac hypertrophy and heart failure. In this review, emphasis is placed on recent progress in our understanding of the transcriptional control of cardiac maturation, encompassing the results of studies spanning from in vivo models to cardiomyocytes derived from human stem cells. The potential applications of this current state of knowledge to new translational avenues aimed at the treatment of heart failure is also addressed.
摘要
出生后，心脏会经历一个动态的成熟过程，以应对各种刺激，包括生理和病理信号。这个过程需要对线粒体能量代谢进行大量的重新编程，同时出现专门的结构和收缩机制，以满足成年心脏的需求。在病理性心脏肥大和心力衰竭的发展过程中，这个程序的许多组成部分会恢复到更“胎儿”的形式。在这篇综述中，重点是我们对心脏成熟转录控制的最新理解进展，包括从体内模型到人类干细胞衍生的心肌细胞的研究结果。还讨论了这种当前知识状态在旨在治疗心力衰竭的新转化途径中的潜在应用。
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