Sieben G, Calliauw L, van Oostveldt P, Roels H
Eur J Cancer Clin Oncol. 1985 Feb;21(2):217-20. doi: 10.1016/0277-5379(85)90176-2.
The influence of AZQ, a chemotherapeutic agent, on the DNA-distribution of human cerebral tumours in short-term culture was studied by means of a MPV II cytofluorometer. The cell cultures were exposed to increasing concentrations of AZQ during 5 days. The results showed that AZQ has no cell phase-specific activity. The influence on the DNA-distribution varied considerably in the examined tumours. It is hypothesised that the effect of AZQ might depend upon the initial DNA-distribution of human cerebral tumours, hyperdiploid tumours being more vulnerable.
利用MPV II细胞荧光光度计研究了化疗药物AZQ对短期培养的人脑肿瘤DNA分布的影响。细胞培养物在5天内暴露于浓度不断增加的AZQ中。结果表明，AZQ没有细胞周期特异性活性。在所检测的肿瘤中，其对DNA分布的影响差异很大。据推测，AZQ的作用可能取决于人脑肿瘤最初的DNA分布，超二倍体肿瘤可能更易受影响。
