体外突触可塑性：介导短期习惯化和敏感化的特定海兔神经元的细胞培养
Synaptic plasticity in vitro: cell culture of identified Aplysia neurons mediating short-term habituation and sensitization.
作者信息
Rayport S G, Schacher S
出版信息
J Neurosci. 1986 Mar;6(3):759-63. doi: 10.1523/JNEUROSCI.06-03-00759.1986.
Abstract
The gill withdrawal reflex of the marine mollusk, Aplysia californica, shows habituation and sensitization, two simple forms of learning. In order to extend the cellular studies on synaptic plasticity underlying the changes in the reflex behavior, and to explore further the development of synaptic plasticity during synapse formation, we have sought to establish the neural circuit of the gill withdrawal reflex in vitro. We report here the reconstruction of the elementary gill withdrawal circuit in cell culture and find that the cells show short-term homosynaptic depression and heterosynaptic facilitation, the cellular mechanisms of habituation and sensitization, respectively.
摘要
海生软体动物加州海兔的鳃收缩反射表现出习惯化和敏感化，这是两种简单的学习形式。为了拓展对反射行为变化背后的突触可塑性的细胞研究，并进一步探索突触形成过程中突触可塑性的发展，我们试图在体外建立鳃收缩反射的神经回路。我们在此报告细胞培养中基本鳃收缩回路的重建，并发现细胞表现出短期同突触抑制和异突触易化，分别是习惯化和敏感化的细胞机制。
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