Nevoit Ganna, Jarusevicius Gediminas, Potyazhenko Maksim, Mintser Ozar, Bumblyte Inga Arune, Vainoras Alfonsas
Laboratory of Population Studies, Cardiology Institute, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Laboratory for Automatization of Cardiovascular Investigations, Cardiology Institute, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Diseases. 2024 Nov 2;12(11):277. doi: 10.3390/diseases12110277.
BACKGROUND/OBJECTIVES: Noncommunicable diseases (NCDs) are a very important medical problem. The key role of mitochondrial dysfunction (MD) in the occurrence and progression of NCDs has been proven. However, the etiology and pathogenesis of MD itself in many NCDs has not yet been clarified, which makes it one of the most serious medical problems in the modern world, according to many scientists.
An extensive research in the literature was implemented in order to elucidate the role of MD and NCDs' risk factors in the pathogenesis of NCDs.
The authors propose to take a broader look at the problem of the pathogenesis of NCDs. It is important to understand exactly how NCD risk factors lead to MD. The review is structured in such a way as to answer this question. Based on a systematic analysis of scientific data, a theoretical concept of modern views on the occurrence of MD under the influence of risk factors for the occurrence of NCDs is presented. This was done in order to update MD issues in clinical medicine. MD and NCDs progress throughout a patient's life. Based on this, the review raised the question of the existence of an NCDs continuum.
MD is a universal mechanism that causes organ dysfunction and comorbidity of NCDs. Prevention of MD involves diagnosing and eliminating the factors that cause it. Mitochondria are an important therapeutic target.
背景/目的：非传染性疾病（NCDs）是一个非常重要的医学问题。线粒体功能障碍（MD）在非传染性疾病发生和发展中的关键作用已得到证实。然而，许多非传染性疾病中MD本身的病因和发病机制尚未阐明，据许多科学家称，这使其成为现代世界最严重的医学问题之一。
对文献进行了广泛研究，以阐明MD和非传染性疾病危险因素在非传染性疾病发病机制中的作用。
作者建议更全面地看待非传染性疾病的发病机制问题。确切了解非传染性疾病危险因素如何导致MD非常重要。综述的结构旨在回答这个问题。基于对科学数据的系统分析，提出了关于在非传染性疾病发生危险因素影响下MD发生的现代观点的理论概念。这样做是为了更新临床医学中的MD问题。MD和非传染性疾病在患者一生中都会进展。基于此，综述提出了非传染性疾病连续体是否存在的问题。
MD是导致器官功能障碍和非传染性疾病合并症的普遍机制。预防MD涉及诊断和消除导致它的因素。线粒体是一个重要的治疗靶点。
