Riera Aroche Raul, Ortiz García Yveth M, Sánchez Moreno Esli C, Enriquez Cervantes José S, Machado Sulbaran Andrea C, Riera Leal Annie
Department of Research in Physics, Division of Natural Sciences and Mathematics, University of Sonora, Hermosillo 83000, Mexico.
Research and Higher Education Center of UNEPROP, Hermosillo 83105, Mexico.
Curr Issues Mol Biol. 2024 Oct 30;46(11):12152-12173. doi: 10.3390/cimb46110721.
Previously, we described that Adenine, Thymine, Cytosine, and Guanine nucleobases were superconductors in a quantum superposition of phases on each side of the central hydrogen bond acting as a Josephson Junction. Genomic DNA has two strands wrapped helically around one another, but during transcription, they are separated by the RNA polymerase II to form a molecular condensate called the transcription bubble. Successive steps involve the bubble translocation along the gene body. This work aims to modulate DNA as a combination of -nonperturbative circuits quantum electrodynamics with nine Radio-Frequency Superconducting Quantum Interference Devices (SQUIDs) inside. A bus can be coupled capacitively to a single-mode microwave resonator. The cavity mode and the bus can mediate long-range, fast interaction between neighboring and distant DNA SQUID qubits. RNA polymerase II produces decoherence during transcription. This enzyme is a multifunctional biomolecular machine working like an artificially engineered device. Phosphorylation catalyzed by protein kinases constitutes the driving force. The coupling between n-phosphorylation pulses and any particular SQUID qubit can be obtained selectively via frequency matching.
此前，我们曾描述过，腺嘌呤、胸腺嘧啶、胞嘧啶和鸟嘌呤核苷酸碱基在作为约瑟夫森结的中心氢键两侧的量子叠加相中是超导体。基因组DNA有两条相互螺旋缠绕的链，但在转录过程中，它们会被RNA聚合酶II分开，形成一种称为转录泡的分子凝聚物。后续步骤包括转录泡沿基因体的移位。这项工作旨在将DNA调制为内部带有九个射频超导量子干涉器件（SQUID）的非微扰电路量子电动力学的组合。一条总线可以电容性耦合到单模微波谐振器。腔模和总线可以介导相邻和远距离DNA SQUID量子比特之间的长程、快速相互作用。RNA聚合酶II在转录过程中会产生退相干。这种酶是一种多功能生物分子机器，其工作方式类似于人工设计的装置。蛋白激酶催化的磷酸化构成驱动力。通过频率匹配可以选择性地获得n-磷酸化脉冲与任何特定SQUID量子比特之间的耦合。
