Kis-György Rita, Körtési Tamás, Anicka Alexandra, Nagy-Grócz Gábor
Section of Health Behaviour and Health Promotion, Faculty of Health Sciences and Social Studies, University of Szeged, Temesvári krt. 31., H-6726 Szeged, Hungary.
Doctoral School of Interdisciplinary Medicine, University of Szeged, Szőkefalvi-Nagy Béla u. 4/B, H-6720 Szeged, Hungary.
Curr Issues Mol Biol. 2024 Nov 7;46(11):12641-12657. doi: 10.3390/cimb46110750.
The oral microbiome, comprising bacteria, fungi, viruses, and protozoa, is essential for maintaining both oral and systemic health. This complex ecosystem includes over 700 bacterial species, such as , which contributes to dental caries through acid production that demineralizes tooth enamel. Fungi like Candida and pathogens such as are also significant, as they can lead to periodontal diseases through inflammation and destruction of tooth-supporting structures. Dysbiosis, or microbial imbalance, is a key factor in the development of these oral diseases. Understanding the composition and functions of the oral microbiome is vital for creating targeted therapies for these conditions. Additionally, the kynurenine pathway, which processes the amino acid tryptophan, plays a crucial role in immune regulation, neuroprotection, and inflammation. Oral bacteria can metabolize tryptophan, influencing the production of kynurenine, kynurenic acid, and quinolinic acid, thereby affecting the kynurenine system. The balance of microbial species in the oral cavity can impact tryptophan levels and its metabolites. This narrative review aims to explore the relationship between the oral microbiome, oral diseases, and the kynurenine system in relation to certain systemic diseases.
口腔微生物群由细菌、真菌、病毒和原生动物组成，对维持口腔和全身健康至关重要。这个复杂的生态系统包括700多种细菌，例如 ，它通过产酸使牙釉质脱矿质从而导致龋齿。像念珠菌这样的真菌和诸如 这样的病原体也很重要，因为它们可通过炎症和破坏牙齿支持结构而导致牙周疾病。生态失调，即微生物失衡，是这些口腔疾病发生发展的关键因素。了解口腔微生物群的组成和功能对于为这些病症制定靶向治疗至关重要。此外，处理氨基酸色氨酸的犬尿氨酸途径在免疫调节、神经保护和炎症中起关键作用。口腔细菌可代谢色氨酸，影响犬尿氨酸、犬尿酸和喹啉酸的产生，从而影响犬尿氨酸系统。口腔中微生物种类的平衡会影响色氨酸水平及其代谢产物。本叙述性综述旨在探讨口腔微生物群、口腔疾病以及犬尿氨酸系统与某些全身性疾病之间的关系。
